| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C3orf70 | CYTH4 | ENSP00000334974 | ENSP00000248901 | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP; Pleckstrin homology domain containing | 0.447 |
| C3orf70 | ELFN2 | ENSP00000334974 | ENSP00000385277 | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.491 |
| C3orf70 | POC1A | ENSP00000334974 | ENSP00000296484 | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation; Belongs to the WD repeat POC1 family | 0.445 |
| C3orf70 | ZFP69B | ENSP00000334974 | ENSP00000399664 | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.572 |
| CCDC39 | CCDC79 | ENSP00000405708 | ENSP00000463762 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | 0.605 |
| CCDC39 | ZFP69B | ENSP00000405708 | ENSP00000399664 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.418 |
| CCDC79 | CCDC39 | ENSP00000463762 | ENSP00000405708 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | 0.605 |
| CCDC79 | ZFP69B | ENSP00000463762 | ENSP00000399664 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes- in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and [...] | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.406 |
| CYTH4 | C3orf70 | ENSP00000248901 | ENSP00000334974 | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP; Pleckstrin homology domain containing | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | 0.447 |
| CYTH4 | POC1A | ENSP00000248901 | ENSP00000296484 | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP; Pleckstrin homology domain containing | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation; Belongs to the WD repeat POC1 family | 0.453 |
| CYTH4 | ZFP69B | ENSP00000248901 | ENSP00000399664 | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP; Pleckstrin homology domain containing | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.441 |
| ELFN2 | C3orf70 | ENSP00000385277 | ENSP00000334974 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | 0.491 |
| ELFN2 | ZFP69B | ENSP00000385277 | ENSP00000399664 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.474 |
| POC1A | C3orf70 | ENSP00000296484 | ENSP00000334974 | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation; Belongs to the WD repeat POC1 family | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family | 0.445 |
| POC1A | CYTH4 | ENSP00000296484 | ENSP00000248901 | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation; Belongs to the WD repeat POC1 family | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP; Pleckstrin homology domain containing | 0.453 |
| POC1A | ZFP69B | ENSP00000296484 | ENSP00000399664 | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation; Belongs to the WD repeat POC1 family | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.454 |
| SMAP2 | TMCO2 | ENSP00000361803 | ENSP00000361852 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | Transmembrane and coiled-coil domains 2 | 0.640 |
| SMAP2 | ZDHHC23 | ENSP00000361803 | ENSP00000330485 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane; Zinc fingers DHHC-type | 0.604 |
| SMAP2 | ZFP69B | ENSP00000361803 | ENSP00000399664 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.672 |
| TMCO2 | SMAP2 | ENSP00000361852 | ENSP00000361803 | Transmembrane and coiled-coil domains 2 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network (By similarity); ArfGAPs | 0.640 |
