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STRINGSTRING
HP HP PANX1 PANX1 ALDH5A1 ALDH5A1 GPLD1 GPLD1 MRS2 MRS2 CNNM2 CNNM2 NIPAL1 NIPAL1 SLC41A2 SLC41A2 SLC41A1 SLC41A1 TRPM6 TRPM6 TRPM7 TRPM7
"MRS2" - Magnesium transporter MRS2 homolog, mitochondrial in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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some 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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MRS2Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family (446 aa)    
Predicted Functional Partners:
SLC41A1
Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Solute carriers (513 aa)
      
   
  0.736
PANX1
Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Pannexins (426 aa)
            
  0.700
GPLD1
Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane (840 aa)
      
   
  0.693
TRPM6
Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region; In the N-terminal section; belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM6 sub-subfamily (2022 aa)
      
   
  0.668
HP
Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...] (406 aa)
            
  0.630
ALDH5A1
Succinate-semialdehyde dehydrogenase, mitochondrial; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA); Aldehyde dehydrogenases (548 aa)
      
   
  0.622
TRPM7
Transient receptor potential cation channel subfamily M member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin [...] (1865 aa)
      
   
  0.607
SLC41A2
Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter; Solute carriers (573 aa)
            
  0.601
CNNM2
Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) (875 aa)
      
   
  0.598
NIPAL1
Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity) (410 aa)
      
   
  0.595
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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