node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP5B1 | C11orf68 | ENSP00000454303 | ENSP00000398350 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | 0.556 |
AP5B1 | MACROD1 | ENSP00000454303 | ENSP00000255681 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | O-acetyl-ADP-ribose deacetylase MACROD1; Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism [...] | 0.483 |
AP5B1 | NRXN2 | ENSP00000454303 | ENSP00000265459 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling; Neurexins | 0.491 |
C11orf68 | AP5B1 | ENSP00000398350 | ENSP00000454303 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | 0.556 |
C11orf68 | CSDE1 | ENSP00000398350 | ENSP00000481762 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain | 0.723 |
C11orf68 | DRAP1 | ENSP00000398350 | ENSP00000307850 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own | 0.465 |
C11orf68 | EIF4H | ENSP00000398350 | ENSP00000265753 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing | 0.710 |
C11orf68 | MACROD1 | ENSP00000398350 | ENSP00000255681 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | O-acetyl-ADP-ribose deacetylase MACROD1; Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism [...] | 0.513 |
C11orf68 | MINA | ENSP00000398350 | ENSP00000328251 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated ’Lys-9’ on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on ’His-39’. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles; Belongs to the ROX family. MINA53 subfamily | 0.556 |
C11orf68 | NRXN2 | ENSP00000398350 | ENSP00000265459 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling; Neurexins | 0.451 |
C11orf68 | PSMA4 | ENSP00000398350 | ENSP00000044462 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.566 |
C11orf68 | TMEM156 | ENSP00000398350 | ENSP00000371364 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Transmembrane protein 156 | 0.514 |
C11orf68 | TRAPPC2L | ENSP00000398350 | ENSP00000301021 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. Sedlin subfamily | 0.748 |
CSDE1 | C11orf68 | ENSP00000481762 | ENSP00000398350 | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | 0.723 |
CSDE1 | EIF4H | ENSP00000481762 | ENSP00000265753 | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing | 0.406 |
DRAP1 | C11orf68 | ENSP00000307850 | ENSP00000398350 | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | 0.465 |
EIF4H | C11orf68 | ENSP00000265753 | ENSP00000398350 | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family | 0.710 |
EIF4H | CSDE1 | ENSP00000265753 | ENSP00000481762 | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding- region determinant of instability (mCRD) domain | 0.406 |
EIF4H | PSMA4 | ENSP00000265753 | ENSP00000044462 | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing | Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] | 0.410 |
MACROD1 | AP5B1 | ENSP00000255681 | ENSP00000454303 | O-acetyl-ADP-ribose deacetylase MACROD1; Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism [...] | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing | 0.483 |