node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | COL2A1 | ENSP00000387356 | ENSP00000369889 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region; C-type lectin domain containing | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces | 0.449 |
ACAN | SHOX | ENSP00000387356 | ENSP00000370990 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region; C-type lectin domain containing | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.449 |
ACAN | SOX5 | ENSP00000387356 | ENSP00000398273 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region; C-type lectin domain containing | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.699 |
ARID5A | SOX5 | ENSP00000350078 | ENSP00000398273 | AT-rich interactive domain-containing protein 5A; Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer- dependent gene expressison. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early- stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional act [...] | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.806 |
CEP85 | SOX13 | ENSP00000252992 | ENSP00000356172 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Transcription factor SOX-13; Binds to the sequence 5’-AACAAT-3’; SRY-boxes | 0.847 |
CEP85 | SOX5 | ENSP00000252992 | ENSP00000398273 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.827 |
COL2A1 | ACAN | ENSP00000369889 | ENSP00000387356 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region; C-type lectin domain containing | 0.449 |
COL2A1 | SOX5 | ENSP00000369889 | ENSP00000398273 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.745 |
ETNK1 | SOX5 | ENSP00000266517 | ENSP00000398273 | Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.800 |
FEZF2 | NEUROG1 | ENSP00000283268 | ENSP00000317580 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity); Basic helix-loop-helix proteins | 0.714 |
FEZF2 | SOX5 | ENSP00000283268 | ENSP00000398273 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.710 |
NEUROG1 | FEZF2 | ENSP00000317580 | ENSP00000283268 | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity); Basic helix-loop-helix proteins | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity); Zinc fingers C2H2-type | 0.714 |
NEUROG1 | SOX5 | ENSP00000317580 | ENSP00000398273 | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity); Basic helix-loop-helix proteins | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.718 |
NKX2-5 | SHOX | ENSP00000327758 | ENSP00000370990 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development; NKL subclass homeoboxes and pseudogenes | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | 0.602 |
NKX2-5 | SOX5 | ENSP00000327758 | ENSP00000398273 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development; NKL subclass homeoboxes and pseudogenes | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.705 |
SHOX | ACAN | ENSP00000370990 | ENSP00000387356 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region; C-type lectin domain containing | 0.449 |
SHOX | NKX2-5 | ENSP00000370990 | ENSP00000327758 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development; NKL subclass homeoboxes and pseudogenes | 0.602 |
SHOX | SOX5 | ENSP00000370990 | ENSP00000398273 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.692 |
SOX13 | CEP85 | ENSP00000356172 | ENSP00000252992 | Transcription factor SOX-13; Binds to the sequence 5’-AACAAT-3’; SRY-boxes | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family | 0.847 |
SOX13 | SOX5 | ENSP00000356172 | ENSP00000398273 | Transcription factor SOX-13; Binds to the sequence 5’-AACAAT-3’; SRY-boxes | Transcription factor SOX-5; Binds specifically to the DNA sequence 5’-AACAAT-3’. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes | 0.858 |