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STRINGSTRING
IFT46 IFT46 IFT140 IFT140 WDR19 WDR19 TTC21A TTC21A IFT74 IFT74 IFT20 IFT20 IFT81 IFT81 IFT43 IFT43 TRAF3IP1 TRAF3IP1 WDR35 WDR35 IFT122 IFT122
"TTC21A" - Tetratricopeptide repeat domain containing in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TTC21ATetratricopeptide repeat domain containing; Belongs to the TTC21 family (1320 aa)    
Predicted Functional Partners:
IFT74
Intraflagellar transport protein 74 homolog; Component of the intraflagellar transport (IFT) complex B- together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis; Belongs to the IFT74 family (600 aa)
      
 
  0.848
IFT81
Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B- together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis; Belongs to the IFT81 family (676 aa)
      
 
  0.835
WDR35
WD repeat-containing protein 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis; Intraflagellar transport proteins (1181 aa)
      
 
  0.835
IFT140
Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance. May play a role in ciliary assembly. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity); Intraflagellar transport proteins (1462 aa)
      
 
  0.827
IFT122
Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity); Intraflagellar transport proteins (1292 aa)
      
 
  0.777
WDR19
WD repeat-containing protein 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity). Associates with the BBSome complex to mediate ciliary transport (By similarity); Intraflagellar transport proteins (1342 aa)
      
 
  0.725
IFT46
Intraflagellar transport proteins; Cilia and flagella associated (355 aa)
      
  0.716
IFT20
Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (158 aa)
      
 
  0.714
IFT43
Intraflagellar transport proteins (213 aa)
          
  0.708
TRAF3IP1
TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis (By similarity); Intraflagellar transport proteins (691 aa)
      
 
  0.705
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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