| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATRX | SP140L | ENSP00000362441 | ENSP00000397911 | Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3- containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX-DAXX which has ATP-dependent DNA translocase [...] | SP140 nuclear body protein like; Bromodomain containing | 0.487 |
| BLK | SP140 | ENSP00000259089 | ENSP00000375899 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.673 |
| BLK | SP140L | ENSP00000259089 | ENSP00000397911 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | SP140 nuclear body protein like; Bromodomain containing | 0.635 |
| DPRX | SP140 | ENSP00000365838 | ENSP00000375899 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | 0.706 |
| DPRX | SP140L | ENSP00000365838 | ENSP00000397911 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | SP140 nuclear body protein like; Bromodomain containing | 0.514 |
| DPRX | SUGCT | ENSP00000365838 | ENSP00000338475 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family | 0.664 |
| FAM109B | PRR18 | ENSP00000312753 | ENSP00000319590 | Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian family | Proline-rich protein 18; Proline rich 18 | 0.552 |
| FAM109B | SP140L | ENSP00000312753 | ENSP00000397911 | Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian family | SP140 nuclear body protein like; Bromodomain containing | 0.539 |
| GMEB1 | SP140L | ENSP00000294409 | ENSP00000397911 | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses | SP140 nuclear body protein like; Bromodomain containing | 0.501 |
| PRR18 | FAM109B | ENSP00000319590 | ENSP00000312753 | Proline-rich protein 18; Proline rich 18 | Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian family | 0.552 |
| PRR18 | SP140L | ENSP00000319590 | ENSP00000397911 | Proline-rich protein 18; Proline rich 18 | SP140 nuclear body protein like; Bromodomain containing | 0.495 |
| SP140 | BLK | ENSP00000375899 | ENSP00000259089 | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | 0.673 |
| SP140 | DPRX | ENSP00000375899 | ENSP00000365838 | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | 0.706 |
| SP140 | SP140L | ENSP00000375899 | ENSP00000397911 | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | SP140 nuclear body protein like; Bromodomain containing | 0.775 |
| SP140 | SUGCT | ENSP00000375899 | ENSP00000338475 | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing | Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family | 0.651 |
| SP140L | ATRX | ENSP00000397911 | ENSP00000362441 | SP140 nuclear body protein like; Bromodomain containing | Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3- containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX-DAXX which has ATP-dependent DNA translocase [...] | 0.487 |
| SP140L | BLK | ENSP00000397911 | ENSP00000259089 | SP140 nuclear body protein like; Bromodomain containing | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] | 0.635 |
| SP140L | DPRX | ENSP00000397911 | ENSP00000365838 | SP140 nuclear body protein like; Bromodomain containing | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes | 0.514 |
| SP140L | FAM109B | ENSP00000397911 | ENSP00000312753 | SP140 nuclear body protein like; Bromodomain containing | Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian family | 0.539 |
| SP140L | GMEB1 | ENSP00000397911 | ENSP00000294409 | SP140 nuclear body protein like; Bromodomain containing | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses | 0.501 |
