ENDOU protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENDOU

Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases (410 aa)

Predicted Functional Partners:

STS

0.716

TMEM45B

0.700

LGALS13

0.676

POP4

0.616

OOSP2

0.614

RBMX2

0.596

PPEF1

0.586

SARS2

0.584

ENSG00000269547

0.584

NUTF2

0.572

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENDOU	ENSG00000269547	ENSP00000397679	ENSP00000472465	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Uncharacterized protein; Serine--tRNA ligase, mitochondrial	0.584
ENDOU	LGALS13	ENSP00000397679	ENSP00000221797	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins	0.676
ENDOU	NUTF2	ENSP00000397679	ENSP00000219169	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import	0.572
ENDOU	OOSP2	ENSP00000397679	ENSP00000278855	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Oocyte secreted protein 2	0.614
ENDOU	POP4	ENSP00000397679	ENSP00000465213	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Ribonuclease P protein subunit p29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	0.616
ENDOU	PPEF1	ENSP00000397679	ENSP00000354871	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development; EF-hand domain containing	0.586
ENDOU	RBMX2	ENSP00000397679	ENSP00000339090	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	RNA binding motif protein, X-linked 2	0.596
ENDOU	SARS2	ENSP00000397679	ENSP00000472847	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec); Aminoacyl tRNA synthetases, Class II	0.584
ENDOU	STS	ENSP00000397679	ENSP00000217961	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases	0.716
ENDOU	TMEM45B	ENSP00000397679	ENSP00000281441	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	Transmembrane protein 45B	0.700
ENSG00000269547	ENDOU	ENSP00000472465	ENSP00000397679	Uncharacterized protein; Serine--tRNA ligase, mitochondrial	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	0.584
LGALS13	ENDOU	ENSP00000221797	ENSP00000397679	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	0.676
LGALS13	NUTF2	ENSP00000221797	ENSP00000219169	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins	Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import	0.476
LGALS13	PPEF1	ENSP00000221797	ENSP00000354871	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins	Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development; EF-hand domain containing	0.526
NUTF2	ENDOU	ENSP00000219169	ENSP00000397679	Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	0.572
NUTF2	LGALS13	ENSP00000219169	ENSP00000221797	Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins	0.476
NUTF2	PPEF1	ENSP00000219169	ENSP00000354871	Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import	Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development; EF-hand domain containing	0.426
OOSP2	ENDOU	ENSP00000278855	ENSP00000397679	Oocyte secreted protein 2	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	0.614
POP4	ENDOU	ENSP00000465213	ENSP00000397679	Ribonuclease P protein subunit p29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends. May function with RPP38 to coordinate the nucleolar targeting and/or assembly of RNase P	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	0.616
PPEF1	ENDOU	ENSP00000354871	ENSP00000397679	Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development; EF-hand domain containing	Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2’-3’-cyclic phosphate termini; Serine proteases	0.586

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About