| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCCIP | PAPD4 | ENSP00000357748 | ENSP00000397563 | BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in [...] | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | 0.735 |
| BCCIP | XRN2 | ENSP00000357748 | ENSP00000366396 | BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in [...] | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites | 0.463 |
| BICC1 | CPEB1 | ENSP00000362993 | ENSP00000477715 | Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | 0.475 |
| BICC1 | PAPD4 | ENSP00000362993 | ENSP00000397563 | Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | 0.755 |
| BICC1 | PAPOLA | ENSP00000362993 | ENSP00000216277 | Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing | Poly(A) polymerase alpha; Polymerase that creates the 3’-poly(A) tail of mRNA’s. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus | 0.408 |
| CPEB1 | BICC1 | ENSP00000477715 | ENSP00000362993 | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing | 0.475 |
| CPEB1 | PABPC1L | ENSP00000477715 | ENSP00000255136 | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | 0.750 |
| CPEB1 | PAPD4 | ENSP00000477715 | ENSP00000397563 | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | 0.852 |
| CPEB1 | PARN | ENSP00000477715 | ENSP00000387911 | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | Poly(A)-specific ribonuclease PARN; 3’-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3’-end poly(A) tail and the 5’-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsens [...] | 0.861 |
| CPEB1 | SYMPK | ENSP00000477715 | ENSP00000245934 | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3’-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity; Belongs to the Symplekin family | 0.947 |
| DIS3L2 | PAPD4 | ENSP00000315569 | ENSP00000397563 | DIS3-like exonuclease 2; 3’-5’-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3’ end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3’. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | 0.703 |
| DIS3L2 | PAPOLA | ENSP00000315569 | ENSP00000216277 | DIS3-like exonuclease 2; 3’-5’-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3’ end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3’. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] | Poly(A) polymerase alpha; Polymerase that creates the 3’-poly(A) tail of mRNA’s. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus | 0.418 |
| DIS3L2 | XRN2 | ENSP00000315569 | ENSP00000366396 | DIS3-like exonuclease 2; 3’-5’-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3’ end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3’. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites | 0.745 |
| PABPC1L | CPEB1 | ENSP00000255136 | ENSP00000477715 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | 0.750 |
| PABPC1L | PAPD4 | ENSP00000255136 | ENSP00000397563 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | 0.705 |
| PABPC1L | PARN | ENSP00000255136 | ENSP00000387911 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | Poly(A)-specific ribonuclease PARN; 3’-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3’-end poly(A) tail and the 5’-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsens [...] | 0.688 |
| PABPC1L | SYMPK | ENSP00000255136 | ENSP00000245934 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing | Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3’-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity; Belongs to the Symplekin family | 0.628 |
| PAPD4 | BCCIP | ENSP00000397563 | ENSP00000357748 | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in [...] | 0.735 |
| PAPD4 | BICC1 | ENSP00000397563 | ENSP00000362993 | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alpha motif domain containing | 0.755 |
| PAPD4 | CPEB1 | ENSP00000397563 | ENSP00000477715 | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3’-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation; Belongs to the DNA polymerase type-B-like family. GLD2 subfamily | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5’-UUUUUAU- 3’) within the mRNA 3’-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of tra [...] | 0.852 |
