node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCORL1 | NYAP1 | ENSP00000437775 | ENSP00000300179 | BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor; Belongs to the BCOR family | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; Belongs to the NYAP family | 0.530 |
BCORL1 | ZNF300 | ENSP00000437775 | ENSP00000397178 | BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor; Belongs to the BCOR family | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.514 |
ETV2 | NFKB1 | ENSP00000384524 | ENSP00000226574 | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimer [...] | 0.407 |
ETV2 | NKX2-2 | ENSP00000384524 | ENSP00000366347 | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | 0.428 |
ETV2 | NKX3-2 | ENSP00000384524 | ENSP00000371875 | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity); Belongs to the NK-3 homeobox family | 0.434 |
ETV2 | ZNF300 | ENSP00000384524 | ENSP00000397178 | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.428 |
ETV3 | NKX2-2 | ENSP00000357175 | ENSP00000366347 | ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity; ETS transcription factor family | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | 0.421 |
ETV3 | NKX3-2 | ENSP00000357175 | ENSP00000371875 | ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity; ETS transcription factor family | Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity); Belongs to the NK-3 homeobox family | 0.428 |
ETV3 | ZNF300 | ENSP00000357175 | ENSP00000397178 | ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity; ETS transcription factor family | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.416 |
IRGM | ZNF300 | ENSP00000428220 | ENSP00000397178 | Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.756 |
NFKB1 | ETV2 | ENSP00000226574 | ENSP00000384524 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimer [...] | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | 0.407 |
NFKB1 | ZNF300 | ENSP00000226574 | ENSP00000397178 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimer [...] | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.415 |
NKX2-2 | ETV2 | ENSP00000366347 | ENSP00000384524 | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | 0.428 |
NKX2-2 | ETV3 | ENSP00000366347 | ENSP00000357175 | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity; ETS transcription factor family | 0.421 |
NKX2-2 | ZNF300 | ENSP00000366347 | ENSP00000397178 | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity); Belongs to the NK-2 homeobox family | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.445 |
NKX3-2 | ETV2 | ENSP00000371875 | ENSP00000384524 | Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity); Belongs to the NK-3 homeobox family | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5’-CGGA[AT]-3’; ETS transcription factor family | 0.434 |
NKX3-2 | ETV3 | ENSP00000371875 | ENSP00000357175 | Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity); Belongs to the NK-3 homeobox family | ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity; ETS transcription factor family | 0.428 |
NKX3-2 | ZNF300 | ENSP00000371875 | ENSP00000397178 | Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity); Belongs to the NK-3 homeobox family | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.497 |
NWD1 | ZNF300 | ENSP00000428579 | ENSP00000397178 | NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type | 0.423 |
NYAP1 | BCORL1 | ENSP00000300179 | ENSP00000437775 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; Belongs to the NYAP family | BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor; Belongs to the BCOR family | 0.530 |