PPM1N protein (human) - STRING database

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PPM1N

Protein phosphatase, Mg2+/Mn2+ dependent 1N (430 aa)

Predicted Functional Partners:

MS4A15

0.581

PPP1R37

0.573

KAAG1

0.571

CD3EAP

0.566

OPA3

0.528

KLC3

0.524

RTN2

0.520

NPAS4

0.486

MANSC1

0.476

MARK4

0.461

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD3EAP	MS4A15	ENSP00000465099	ENSP00000386022	DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation; Belongs to the eukaryotic RPA34 RNA polymerase subunit family	Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	0.440
CD3EAP	PPM1N	ENSP00000465099	ENSP00000397050	DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation; Belongs to the eukaryotic RPA34 RNA polymerase subunit family	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.566
CD3EAP	PPP1R37	ENSP00000465099	ENSP00000221462	DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation; Belongs to the eukaryotic RPA34 RNA polymerase subunit family	Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Belongs to the PPP1R37 family	0.420
KAAG1	PPM1N	ENSP00000274766	ENSP00000397050	Kidney associated antigen 1	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.571
KLC3	PPM1N	ENSP00000375810	ENSP00000397050	Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport; Belongs to the kinesin light chain family	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.524
MANSC1	MS4A15	ENSP00000438205	ENSP00000386022	MANSC domain containing 1	Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	0.506
MANSC1	PPM1N	ENSP00000438205	ENSP00000397050	MANSC domain containing 1	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.476
MANSC1	PPP1R37	ENSP00000438205	ENSP00000221462	MANSC domain containing 1	Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Belongs to the PPP1R37 family	0.495
MARK4	PPM1N	ENSP00000262891	ENSP00000397050	MAP/microtubule affinity-regulating kinase 4; Serine/threonine-protein kinase. Phosphorylates the microtubule-associated protein MAPT. Also phosphorylates the microtubule-associated proteins MAP2 and MAP4. Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles. Required for the initiation of axoneme extension during cilium assembly. Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro. Plays a role in cell cycle progression, specifically in the G1/S checkpoint. Reduces neuronal cell survival. Plays a role in energy [...]	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.461
MS4A15	CD3EAP	ENSP00000386022	ENSP00000465099	Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation; Belongs to the eukaryotic RPA34 RNA polymerase subunit family	0.440
MS4A15	MANSC1	ENSP00000386022	ENSP00000438205	Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	MANSC domain containing 1	0.506
MS4A15	PPM1N	ENSP00000386022	ENSP00000397050	Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.581
MS4A15	PPP1R37	ENSP00000386022	ENSP00000221462	Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains	Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Belongs to the PPP1R37 family	0.579
NPAS4	PPM1N	ENSP00000311196	ENSP00000397050	Neuronal PAS domain-containing protein 4; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons [...]	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.486
OPA3	PPM1N	ENSP00000319817	ENSP00000397050	Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator	Protein phosphatase, Mg2+/Mn2+ dependent 1N	0.528
OPA3	RTN2	ENSP00000319817	ENSP00000245923	Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator	Reticulon-2; Reticulon 2	0.560
PPM1N	CD3EAP	ENSP00000397050	ENSP00000465099	Protein phosphatase, Mg2+/Mn2+ dependent 1N	DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation; Belongs to the eukaryotic RPA34 RNA polymerase subunit family	0.566
PPM1N	KAAG1	ENSP00000397050	ENSP00000274766	Protein phosphatase, Mg2+/Mn2+ dependent 1N	Kidney associated antigen 1	0.571
PPM1N	KLC3	ENSP00000397050	ENSP00000375810	Protein phosphatase, Mg2+/Mn2+ dependent 1N	Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport; Belongs to the kinesin light chain family	0.524
PPM1N	MANSC1	ENSP00000397050	ENSP00000438205	Protein phosphatase, Mg2+/Mn2+ dependent 1N	MANSC domain containing 1	0.476

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