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STRINGSTRING
XPO4 XPO4 VEGFB VEGFB DNAJC4 DNAJC4 DNAJC25 DNAJC25 DNAJC18 DNAJC18 DNAJC22 DNAJC22 DNAJC9 DNAJC9 DNAJC24 DNAJC24 DNAJC21 DNAJC21 DNAJC8 DNAJC8 CDC5L CDC5L
"DNAJC4" - DnaJ heat shock protein family member C4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
DNAJC4DnaJ heat shock protein family member C4 (241 aa)    
Predicted Functional Partners:
VEGFB
Vascular endothelial growth factor B; Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis (207 aa)
  
 
   
  0.888
DNAJC21
DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA; DNAJ heat shock proteins (576 aa)
   
 
  0.689
DNAJC18
DnaJ heat shock protein family member C18 (358 aa)
   
 
  0.621
DNAJC25
DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family (360 aa)
     
 
  0.620
DNAJC8
DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins (253 aa)
      
   
  0.605
XPO4
Exportin-4; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate ano [...] (1151 aa)
      
   
  0.591
CDC5L
Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Myb/SANT domain containing (802 aa)
      
 
  0.590
DNAJC22
DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins (341 aa)
   
 
  0.581
DNAJC9
DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins (260 aa)
      
   
  0.571
DNAJC24
DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta); Belongs to the DPH4 family (149 aa)
   
 
  0.566
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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