node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM30 | ZNF697 | ENSP00000358407 | ENSP00000396857 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.555 |
ANKRA2 | ZFYVE16 | ENSP00000296785 | ENSP00000337159 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | 0.530 |
ANKRA2 | ZNF697 | ENSP00000296785 | ENSP00000396857 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.567 |
ARID4A | ZNF697 | ENSP00000347602 | ENSP00000396857 | AT-rich interactive domain-containing protein 4A; Interacts with the viral protein-binding domain of the retinoblastoma protein; AT-rich interaction domain containing | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.469 |
FAM212A | ZNF697 | ENSP00000329735 | ENSP00000396857 | PAK4-inhibitor INKA1; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.478 |
PYROXD1 | ZBED4 | ENSP00000240651 | ENSP00000216268 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily | Zinc finger BED-type containing 4 | 0.420 |
PYROXD1 | ZNF697 | ENSP00000240651 | ENSP00000396857 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.431 |
TRIM28 | ZNF697 | ENSP00000253024 | ENSP00000396857 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.903 |
ZBED4 | PYROXD1 | ENSP00000216268 | ENSP00000240651 | Zinc finger BED-type containing 4 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily | 0.420 |
ZBED4 | ZNF697 | ENSP00000216268 | ENSP00000396857 | Zinc finger BED-type containing 4 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.431 |
ZFYVE16 | ANKRA2 | ENSP00000337159 | ENSP00000296785 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | 0.530 |
ZFYVE16 | ZNF697 | ENSP00000337159 | ENSP00000396857 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.584 |
ZNF608 | ZNF697 | ENSP00000307746 | ENSP00000396857 | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription; Zinc fingers C2H2-type | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.561 |
ZNF608 | ZZZ3 | ENSP00000307746 | ENSP00000359837 | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription; Zinc fingers C2H2-type | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.545 |
ZNF697 | ADAM30 | ENSP00000396857 | ENSP00000358407 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing | 0.555 |
ZNF697 | ANKRA2 | ENSP00000396857 | ENSP00000296785 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | 0.567 |
ZNF697 | ARID4A | ENSP00000396857 | ENSP00000347602 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | AT-rich interactive domain-containing protein 4A; Interacts with the viral protein-binding domain of the retinoblastoma protein; AT-rich interaction domain containing | 0.469 |
ZNF697 | FAM212A | ENSP00000396857 | ENSP00000329735 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | PAK4-inhibitor INKA1; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity | 0.478 |
ZNF697 | PYROXD1 | ENSP00000396857 | ENSP00000240651 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily | 0.431 |
ZNF697 | TRIM28 | ENSP00000396857 | ENSP00000253024 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |