node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf165 | DOPEY1 | ENSP00000358575 | ENSP00000237163 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | 0.774 |
C6orf165 | HDHD1 | ENSP00000358575 | ENSP00000396452 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | 0.790 |
C6orf165 | PGM3 | ENSP00000358575 | ENSP00000425809 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation | 0.658 |
C6orf165 | PNPLA4 | ENSP00000358575 | ENSP00000370430 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase; Patatin like phospholipase domain containing | 0.720 |
C6orf165 | PRSS35 | ENSP00000358575 | ENSP00000358714 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | Serine protease 35 | 0.783 |
C6orf165 | UBE3D | ENSP00000358575 | ENSP00000358762 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome | 0.826 |
C6orf165 | VCX3A | ENSP00000358575 | ENSP00000370479 | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Variable charge X/Y family | 0.448 |
CPPED1 | HDHD1 | ENSP00000371193 | ENSP00000396452 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | 0.745 |
CPPED1 | PNPLA4 | ENSP00000371193 | ENSP00000370430 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase; Patatin like phospholipase domain containing | 0.730 |
DOPEY1 | C6orf165 | ENSP00000237163 | ENSP00000358575 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | 0.774 |
DOPEY1 | HDHD1 | ENSP00000237163 | ENSP00000396452 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | 0.725 |
DOPEY1 | PGM3 | ENSP00000237163 | ENSP00000425809 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation | 0.632 |
DOPEY1 | PNPLA4 | ENSP00000237163 | ENSP00000370430 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase; Patatin like phospholipase domain containing | 0.707 |
DOPEY1 | PRSS35 | ENSP00000237163 | ENSP00000358714 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Serine protease 35 | 0.724 |
DOPEY1 | UBE3D | ENSP00000237163 | ENSP00000358762 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome | 0.773 |
ENOPH1 | HDHD1 | ENSP00000273920 | ENSP00000396452 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene); HAD Asp-based non-protein phosphatases | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | 0.814 |
ENOPH1 | PGM3 | ENSP00000273920 | ENSP00000425809 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene); HAD Asp-based non-protein phosphatases | Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation | 0.874 |
HDHD1 | C6orf165 | ENSP00000396452 | ENSP00000358575 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes | 0.790 |
HDHD1 | CPPED1 | ENSP00000396452 | ENSP00000371193 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family | 0.745 |
HDHD1 | DOPEY1 | ENSP00000396452 | ENSP00000237163 | Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | 0.725 |