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  • 11.0 [archived version]
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ENOPH1 ENOPH1 PGM3 PGM3 PRSS35 PRSS35 DOPEY1 DOPEY1 C6orf165 C6orf165 UBE3D UBE3D HDHD1 HDHD1 PNPLA4 PNPLA4 CPPED1 CPPED1 RFK RFK VCX3A VCX3A
"HDHD1" - Pseudouridine-5'-phosphatase in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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HDHD1Pseudouridine-5’-phosphatase; Dephosphorylates pseudouridine 5’-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family (251 aa)    
Predicted Functional Partners:
PGM3
Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation (570 aa)
   
 
  0.945
PNPLA4
Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase; Patatin like phospholipase domain containing (253 aa)
     
   
  0.882
ENOPH1
Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene); HAD Asp-based non-protein phosphatases (261 aa)
     
      0.814
C6orf165
Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes (622 aa)
     
   
  0.790
UBE3D
E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome (389 aa)
           
  0.783
RFK
Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (155 aa)
 
   
  0.769
CPPED1
Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at ’Ser-473’, blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes; Belongs to the metallophosphoesterase superfamily. CPPED1 family (314 aa)
         
  0.745
PRSS35
Serine protease 35 (413 aa)
           
  0.738
DOPEY1
Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes (2476 aa)
           
  0.725
VCX3A
Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Variable charge X/Y family (186 aa)
         
  0.700
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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