node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRA2 | ZFYVE16 | ENSP00000296785 | ENSP00000337159 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | 0.530 |
ANKRA2 | ZNF302 | ENSP00000296785 | ENSP00000396379 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.542 |
LSM14A | UBA2 | ENSP00000446271 | ENSP00000246548 | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.803 |
LSM14A | ZNF302 | ENSP00000446271 | ENSP00000396379 | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.400 |
SCGB2B2 | UBA2 | ENSP00000469876 | ENSP00000246548 | Secretoglobin family 2B member 2; Secretoglobins | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.491 |
SCGB2B2 | ZNF302 | ENSP00000469876 | ENSP00000396379 | Secretoglobin family 2B member 2; Secretoglobins | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.440 |
TRIM28 | ZNF302 | ENSP00000253024 | ENSP00000396379 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.903 |
UBA2 | LSM14A | ENSP00000246548 | ENSP00000446271 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | 0.803 |
UBA2 | SCGB2B2 | ENSP00000246548 | ENSP00000469876 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | Secretoglobin family 2B member 2; Secretoglobins | 0.491 |
UBA2 | ZNF302 | ENSP00000246548 | ENSP00000396379 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.401 |
ZFYVE16 | ANKRA2 | ENSP00000337159 | ENSP00000296785 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | 0.530 |
ZFYVE16 | ZNF302 | ENSP00000337159 | ENSP00000396379 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.530 |
ZNF302 | ANKRA2 | ENSP00000396379 | ENSP00000296785 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat domain containing | 0.542 |
ZNF302 | LSM14A | ENSP00000396379 | ENSP00000446271 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins | 0.400 |
ZNF302 | SCGB2B2 | ENSP00000396379 | ENSP00000469876 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Secretoglobin family 2B member 2; Secretoglobins | 0.440 |
ZNF302 | TRIM28 | ENSP00000396379 | ENSP00000253024 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.903 |
ZNF302 | UBA2 | ENSP00000396379 | ENSP00000246548 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.401 |
ZNF302 | ZFYVE16 | ENSP00000396379 | ENSP00000337159 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes; Protein phosphatase 1 regulatory subunits | 0.530 |