| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CLPB | ENO2 | ENSP00000294053 | ENSP00000437402 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | 0.407 |
| CLPB | KIAA0141 | ENSP00000294053 | ENSP00000396225 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.601 |
| CLPB | TOR1A | ENSP00000294053 | ENSP00000345719 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases | Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular traffickin [...] | 0.626 |
| CLPB | UBB | ENSP00000294053 | ENSP00000304697 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases | Polyubiquitin-B; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.508 |
| EIF2AK1 | KIAA0141 | ENSP00000199389 | ENSP00000396225 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.547 |
| ENO2 | CLPB | ENSP00000437402 | ENSP00000294053 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases | 0.407 |
| ENO2 | KIAA0141 | ENSP00000437402 | ENSP00000396225 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.654 |
| ENO2 | LMNA | ENSP00000437402 | ENSP00000357283 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | Prelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] | 0.418 |
| ERLEC1 | KIAA0141 | ENSP00000185150 | ENSP00000396225 | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.675 |
| ERLEC1 | OS9 | ENSP00000185150 | ENSP00000318165 | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4; MRH domain containing | 0.990 |
| ERLEC1 | UBB | ENSP00000185150 | ENSP00000304697 | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing | Polyubiquitin-B; Ubiquitin- Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked- Lys-6-linked may be involved in DNA repair; [...] | 0.905 |
| KIAA0141 | CLPB | ENSP00000396225 | ENSP00000294053 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases | 0.601 |
| KIAA0141 | EIF2AK1 | ENSP00000396225 | ENSP00000199389 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at ’Ser- 48’ and ’Ser-51’, thus preventing its recycling. Binds hemin forming a 1-1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | 0.547 |
| KIAA0141 | ENO2 | ENSP00000396225 | ENSP00000437402 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Enolases | 0.654 |
| KIAA0141 | ERLEC1 | ENSP00000396225 | ENSP00000185150 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins; MRH domain containing | 0.675 |
| KIAA0141 | LMNA | ENSP00000396225 | ENSP00000357283 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Prelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] | 0.628 |
| KIAA0141 | OS9 | ENSP00000396225 | ENSP00000318165 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4; MRH domain containing | 0.675 |
| KIAA0141 | STC1 | ENSP00000396225 | ENSP00000290271 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Stanniocalcin-1; Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia | 0.559 |
| KIAA0141 | TMEM9 | ENSP00000396225 | ENSP00000356301 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Transmembrane protein 9; May be involved in intracellular transport | 0.580 |
| KIAA0141 | TOR1A | ENSP00000396225 | ENSP00000345719 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular traffickin [...] | 0.711 |
