| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTR10 | CTSA | ENSP00000254286 | ENSP00000361562 | Actin related protein 10 homolog; Belongs to the actin family | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.913 |
| ACTR10 | FUCA1 | ENSP00000254286 | ENSP00000363603 | Actin related protein 10 homolog; Belongs to the actin family | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | 0.900 |
| ACTR10 | GLA | ENSP00000254286 | ENSP00000218516 | Actin related protein 10 homolog; Belongs to the actin family | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.900 |
| ACTR10 | GLB1 | ENSP00000254286 | ENSP00000306920 | Actin related protein 10 homolog; Belongs to the actin family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.900 |
| ACTR10 | GRN | ENSP00000254286 | ENSP00000053867 | Actin related protein 10 homolog; Belongs to the actin family | Granulins; Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling | 0.900 |
| ACTR10 | GUSB | ENSP00000254286 | ENSP00000302728 | Actin related protein 10 homolog; Belongs to the actin family | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.901 |
| ACTR10 | HEXB | ENSP00000254286 | ENSP00000261416 | Actin related protein 10 homolog; Belongs to the actin family | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.903 |
| ACTR10 | MAN2B1 | ENSP00000254286 | ENSP00000395473 | Actin related protein 10 homolog; Belongs to the actin family | Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages; Belongs to the glycosyl hydrolase 38 family | 0.931 |
| ACTR10 | NPC2 | ENSP00000254286 | ENSP00000451112 | Actin related protein 10 homolog; Belongs to the actin family | Epididymal secretory protein E1; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding po [...] | 0.901 |
| CTSA | ACTR10 | ENSP00000361562 | ENSP00000254286 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Actin related protein 10 homolog; Belongs to the actin family | 0.913 |
| CTSA | FUCA1 | ENSP00000361562 | ENSP00000363603 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | 0.924 |
| CTSA | GLA | ENSP00000361562 | ENSP00000218516 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.967 |
| CTSA | GLB1 | ENSP00000361562 | ENSP00000306920 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.993 |
| CTSA | GRN | ENSP00000361562 | ENSP00000053867 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Granulins; Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling | 0.960 |
| CTSA | GUSB | ENSP00000361562 | ENSP00000302728 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.923 |
| CTSA | HEXB | ENSP00000361562 | ENSP00000261416 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.935 |
| CTSA | MAN2B1 | ENSP00000361562 | ENSP00000395473 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages; Belongs to the glycosyl hydrolase 38 family | 0.934 |
| CTSA | NPC2 | ENSP00000361562 | ENSP00000451112 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Epididymal secretory protein E1; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding po [...] | 0.952 |
| FUCA1 | ACTR10 | ENSP00000363603 | ENSP00000254286 | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | Actin related protein 10 homolog; Belongs to the actin family | 0.900 |
| FUCA1 | CTSA | ENSP00000363603 | ENSP00000361562 | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.924 |
