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  • 11.0 [archived version]
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STX3 STX3 RAB3A RAB3A RAB27A RAB27A RAB27B RAB27B UNC13D UNC13D SYTL5 SYTL5 EXPH5 EXPH5 MAP3K15 MAP3K15 ARSF ARSF IL1RAPL1 IL1RAPL1 MAP7D3 MAP7D3
"SYTL5" - Synaptotagmin-like protein 5 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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SYTL5Synaptotagmin-like protein 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids; Synaptotagmin like tandem C2 proteins (752 aa)    
Predicted Functional Partners:
RAB27A
Ras-related protein Rab-27A; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse; RAB, member RAS oncogene GTPases (221 aa)
       
 
  0.785
RAB27B
Ras-related protein Rab-27B; May be involved in targeting uroplakins to urothelial apical membranes; RAB, member RAS oncogene GTPases (218 aa)
     
 
  0.760
UNC13D
Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells; UNC13 homologs (1090 aa)
     
   
  0.658
RAB3A
Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal; RAB, member RAS oncogene GTPases (220 aa)
     
 
  0.611
ARSF
Arylsulfatase F; Sulfatases (590 aa)
     
   
  0.607
MAP3K15
Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily (1313 aa)
           
  0.571
EXPH5
Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking (1989 aa)
           
  0.565
IL1RAPL1
Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans- synaptically binding to PTPRD (By similarity); Belongs to the interleukin-1 receptor family (696 aa)
     
   
  0.565
MAP7D3
MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules (876 aa)
     
   
  0.552
STX3
Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family (289 aa)
       
 
  0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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