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STRINGSTRING
FRRS1L FRRS1L ABHD6 ABHD6 GSG1L GSG1L CNIH3 CNIH3 CACNG2 CACNG2 CNIH2 CNIH2 CNIH1 CNIH1 SHISA9 SHISA9 SYNDIG1 SYNDIG1 RBM10 RBM10 VWC2 VWC2
"GSG1L" - Germ cell-specific gene 1-like protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GSG1LGerm cell-specific gene 1-like protein; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating (331 aa)    
Predicted Functional Partners:
SYNDIG1
Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin family (258 aa)
      
   
  0.804
SHISA9
Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses (By similarity); Belongs to the shisa family. SHISA9 subfamily (424 aa)
      
   
  0.731
VWC2
Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity) (325 aa)
      
   
  0.726
FRRS1L
DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway (344 aa)
      
   
  0.708
CNIH2
Protein cornichon homolog 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors; Belongs to the cornichon family (160 aa)
      
   
  0.693
CACNG2
Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily (323 aa)
      
   
  0.686
CNIH1
Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF-alpha family proteins; Belongs to the cornichon family (144 aa)
      
   
  0.684
RBM10
RNA-binding protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins; G-patch domain containing (995 aa)
            
  0.677
ABHD6
Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity); Belongs to the AB hydrolase superfamily (337 aa)
      
   
  0.649
CNIH3
Protein cornichon homolog 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization; Belongs to the cornichon family (160 aa)
      
   
  0.638
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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