PPT1 protein (human) - STRING database

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PPT1

Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family (306 aa)

Predicted Functional Partners:

CLN3

0.907

MECR

0.905

PPT2

0.861

ENSG00000261832

0.846

LYPLA1

0.838

CLN5

0.835

CLN6

0.832

CLN8

0.818

LYPLA2

0.770

TPP1

0.768

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLN3	CLN5	ENSP00000454229	ENSP00000366673	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	0.910
CLN3	CLN6	ENSP00000454229	ENSP00000249806	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	CLN6, transmembrane ER protein	0.895
CLN3	CLN8	ENSP00000454229	ENSP00000328182	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing	0.870
CLN3	PPT1	ENSP00000454229	ENSP00000394863	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family	0.907
CLN3	PPT2	ENSP00000454229	ENSP00000354608	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins	0.550
CLN3	TPP1	ENSP00000454229	ENSP00000299427	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)	0.766
CLN5	CLN3	ENSP00000366673	ENSP00000454229	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	0.910
CLN5	CLN6	ENSP00000366673	ENSP00000249806	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	CLN6, transmembrane ER protein	0.934
CLN5	CLN8	ENSP00000366673	ENSP00000328182	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing	0.899
CLN5	ENSG00000261832	ENSP00000366673	ENSP00000485589	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	Battenin isoform d	0.918
CLN5	PPT1	ENSP00000366673	ENSP00000394863	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family	0.835
CLN5	PPT2	ENSP00000366673	ENSP00000354608	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins	0.517
CLN5	TPP1	ENSP00000366673	ENSP00000299427	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)	0.827
CLN6	CLN3	ENSP00000249806	ENSP00000454229	CLN6, transmembrane ER protein	Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes	0.895
CLN6	CLN5	ENSP00000249806	ENSP00000366673	CLN6, transmembrane ER protein	Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane	0.934
CLN6	CLN8	ENSP00000249806	ENSP00000328182	CLN6, transmembrane ER protein	Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing	0.906
CLN6	ENSG00000261832	ENSP00000249806	ENSP00000485589	CLN6, transmembrane ER protein	Battenin isoform d	0.889
CLN6	PPT1	ENSP00000249806	ENSP00000394863	CLN6, transmembrane ER protein	Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons; Belongs to the palmitoyl-protein thioesterase family	0.832
CLN6	PPT2	ENSP00000249806	ENSP00000354608	CLN6, transmembrane ER protein	Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins	0.645
CLN6	TPP1	ENSP00000249806	ENSP00000299427	CLN6, transmembrane ER protein	Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)	0.789

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