• Version:
  • 11.0 [archived version]
STRINGSTRING
INAFM1 INAFM1 TP53BP1 TP53BP1 CSN1S1 CSN1S1 PRR12 PRR12 NOSIP NOSIP PRRG2 PRRG2 SCAF1 SCAF1 RCN1 RCN1 BCL2L12 BCL2L12 IMMP1L IMMP1L MPPED2 MPPED2
"PRR12" - Proline-rich protein 12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRR12Proline-rich protein 12; Proline rich 12 (2036 aa)    
Predicted Functional Partners:
SCAF1
Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing (1312 aa)
 
 
   
  0.909
PRRG2
Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing (202 aa)
           
  0.857
IMMP1L
Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (166 aa)
           
  0.714
MPPED2
Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity); Belongs to the UPF0046 family (294 aa)
           
  0.707
BCL2L12
Bcl-2-like protein 12; BCL2 like 12 (334 aa)
           
  0.706
RCN1
Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; EF-hand domain containing (331 aa)
           
  0.694
TP53BP1
TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] (1977 aa)
       
      0.673
INAFM1
Putative transmembrane protein INAFM1; InaF motif containing 1 (142 aa)
     
   
  0.659
NOSIP
Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family (301 aa)
     
   
  0.656
CSN1S1
Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family (185 aa)
           
  0.651
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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