node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GNPDA2 | KCTD15 | ENSP00000295448 | ENSP00000394390 | Glucosamine-6-phosphate deaminase 2 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | 0.868 |
GNPDA2 | MTCH2 | ENSP00000295448 | ENSP00000303222 | Glucosamine-6-phosphate deaminase 2 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers | 0.845 |
GNPDA2 | NEGR1 | ENSP00000295448 | ENSP00000350364 | Glucosamine-6-phosphate deaminase 2 | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belongs to the immunoglobulin superfamily. IgLON family | 0.838 |
GNPDA2 | SH2B1 | ENSP00000295448 | ENSP00000321221 | Glucosamine-6-phosphate deaminase 2 | SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (’Tyr-813’) JAK2 recruits SH2B1, which in turn is phosphoryla [...] | 0.837 |
GNPDA2 | TFAP2B | ENSP00000295448 | ENSP00000377265 | Glucosamine-6-phosphate deaminase 2 | Transcription factor AP-2-beta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and f [...] | 0.683 |
GNPDA2 | TMEM18 | ENSP00000295448 | ENSP00000281017 | Glucosamine-6-phosphate deaminase 2 | Transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC); Belongs to the TMEM18 family | 0.891 |
KCTD15 | GNPDA2 | ENSP00000394390 | ENSP00000295448 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Glucosamine-6-phosphate deaminase 2 | 0.868 |
KCTD15 | MTCH2 | ENSP00000394390 | ENSP00000303222 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers | 0.860 |
KCTD15 | NEGR1 | ENSP00000394390 | ENSP00000350364 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belongs to the immunoglobulin superfamily. IgLON family | 0.842 |
KCTD15 | SH2B1 | ENSP00000394390 | ENSP00000321221 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (’Tyr-813’) JAK2 recruits SH2B1, which in turn is phosphoryla [...] | 0.862 |
KCTD15 | TFAP2A | ENSP00000394390 | ENSP00000368924 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] | 0.978 |
KCTD15 | TFAP2B | ENSP00000394390 | ENSP00000377265 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Transcription factor AP-2-beta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and f [...] | 0.981 |
KCTD15 | TFAP2C | ENSP00000394390 | ENSP00000201031 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Transcription factor AP-2 gamma; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer | 0.947 |
KCTD15 | TFAP2D | ENSP00000394390 | ENSP00000008391 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Transcription factor AP-2-delta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity) | 0.926 |
KCTD15 | TFAP2E | ENSP00000394390 | ENSP00000362332 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Transcription factor AP-2-epsilon; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity) | 0.950 |
KCTD15 | TMEM18 | ENSP00000394390 | ENSP00000281017 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | Transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC); Belongs to the TMEM18 family | 0.870 |
MTCH2 | GNPDA2 | ENSP00000303222 | ENSP00000295448 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers | Glucosamine-6-phosphate deaminase 2 | 0.845 |
MTCH2 | KCTD15 | ENSP00000303222 | ENSP00000394390 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain | 0.860 |
MTCH2 | NEGR1 | ENSP00000303222 | ENSP00000350364 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belongs to the immunoglobulin superfamily. IgLON family | 0.831 |
MTCH2 | SH2B1 | ENSP00000303222 | ENSP00000321221 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers | SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated (’Tyr-813’) JAK2 recruits SH2B1, which in turn is phosphoryla [...] | 0.831 |