| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAP1 | CDKN2AIPNL | ENSP00000442682 | ENSP00000394183 | Arf-GAP with dual PH domain-containing protein 1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4); ArfGAPs | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.531 |
| CDKN2AIPNL | ADAP1 | ENSP00000394183 | ENSP00000442682 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | Arf-GAP with dual PH domain-containing protein 1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4); ArfGAPs | 0.531 |
| CDKN2AIPNL | DXO | ENSP00000394183 | ENSP00000364498 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5’ end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5’-3’ exonuclease activities. Has decapping activity toward incomplete 5’ end cap mRNAs such as unmethylated 5’ end-capped RNA to release GpppN and 5’ end monophosphate RNA. The 5’ end monophosphate RNA is then degraded by the 5’-3’ exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5’-pyrophosphohydrolase activity by h [...] | 0.422 |
| CDKN2AIPNL | EID2B | ENSP00000394183 | ENSP00000317564 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation | 0.537 |
| CDKN2AIPNL | FBXL18 | ENSP00000394183 | ENSP00000371805 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | F-box/LRR-repeat protein 18; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.706 |
| CDKN2AIPNL | HS3ST1 | ENSP00000394183 | ENSP00000002596 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | Heparan sulfate glucosamine 3-O-sulfotransferase 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site | 0.431 |
| CDKN2AIPNL | MPHOSPH6 | ENSP00000394183 | ENSP00000258169 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D | 0.426 |
| CDKN2AIPNL | XRN1 | ENSP00000394183 | ENSP00000264951 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.526 |
| CDKN2AIPNL | XRN2 | ENSP00000394183 | ENSP00000366396 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites | 0.907 |
| CDKN2AIPNL | ZMYM6 | ENSP00000394183 | ENSP00000349708 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | Zinc finger MYM-type protein 6; Plays a role in the regulation of cell morphology and cytoskeletal organization; Zinc fingers MYM-type | 0.430 |
| CDKN2AIPNL | ZNF93 | ENSP00000394183 | ENSP00000342002 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons- recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5’ end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...] | 0.424 |
| DXO | CDKN2AIPNL | ENSP00000364498 | ENSP00000394183 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5’ end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5’-3’ exonuclease activities. Has decapping activity toward incomplete 5’ end cap mRNAs such as unmethylated 5’ end-capped RNA to release GpppN and 5’ end monophosphate RNA. The 5’ end monophosphate RNA is then degraded by the 5’-3’ exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5’-pyrophosphohydrolase activity by h [...] | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.422 |
| DXO | XRN1 | ENSP00000364498 | ENSP00000264951 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5’ end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5’-3’ exonuclease activities. Has decapping activity toward incomplete 5’ end cap mRNAs such as unmethylated 5’ end-capped RNA to release GpppN and 5’ end monophosphate RNA. The 5’ end monophosphate RNA is then degraded by the 5’-3’ exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5’-pyrophosphohydrolase activity by h [...] | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | 0.948 |
| DXO | XRN2 | ENSP00000364498 | ENSP00000366396 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5’ end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5’-3’ exonuclease activities. Has decapping activity toward incomplete 5’ end cap mRNAs such as unmethylated 5’ end-capped RNA to release GpppN and 5’ end monophosphate RNA. The 5’ end monophosphate RNA is then degraded by the 5’-3’ exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5’-pyrophosphohydrolase activity by h [...] | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites | 0.995 |
| EID2B | CDKN2AIPNL | ENSP00000317564 | ENSP00000394183 | EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.537 |
| EID2B | ZNF93 | ENSP00000317564 | ENSP00000342002 | EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation | Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons- recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1. Not able to repress expression of all subtypes of L1 elements. Binds to the 5’ end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress [...] | 0.450 |
| FBXL18 | CDKN2AIPNL | ENSP00000371805 | ENSP00000394183 | F-box/LRR-repeat protein 18; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.706 |
| HS3ST1 | CDKN2AIPNL | ENSP00000002596 | ENSP00000394183 | Heparan sulfate glucosamine 3-O-sulfotransferase 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.431 |
| MPHOSPH6 | CDKN2AIPNL | ENSP00000258169 | ENSP00000394183 | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.426 |
| XRN1 | CDKN2AIPNL | ENSP00000264951 | ENSP00000394183 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like | 0.526 |
