| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAV1 | DNM2 | ENSP00000339191 | ENSP00000373905 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity); Pleckstrin homology domain containing | 0.978 |
| CAV1 | NOS3 | ENSP00000339191 | ENSP00000297494 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets | 0.994 |
| CAV1 | NOSIP | ENSP00000339191 | ENSP00000470034 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | 0.440 |
| CAV1 | NOSTRIN | ENSP00000339191 | ENSP00000394051 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing | 0.941 |
| CAV1 | WASL | ENSP00000339191 | ENSP00000223023 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity); Wiskott-Aldrich Syndrome protein family | 0.921 |
| DNM2 | CAV1 | ENSP00000373905 | ENSP00000339191 | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity); Pleckstrin homology domain containing | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the interna [...] | 0.978 |
| DNM2 | NOS3 | ENSP00000373905 | ENSP00000297494 | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity); Pleckstrin homology domain containing | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets | 0.930 |
| DNM2 | NOSIP | ENSP00000373905 | ENSP00000470034 | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity); Pleckstrin homology domain containing | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family | 0.451 |
| DNM2 | NOSTRIN | ENSP00000373905 | ENSP00000394051 | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity); Pleckstrin homology domain containing | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing | 0.948 |
| DNM2 | WASL | ENSP00000373905 | ENSP00000223023 | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity); Pleckstrin homology domain containing | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Plays a role in dendrite spine morphogenesis (By similarity); Wiskott-Aldrich Syndrome protein family | 0.965 |
| GLB1 | MARS2 | ENSP00000306920 | ENSP00000282276 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | 0.731 |
| GLB1 | NOSTRIN | ENSP00000306920 | ENSP00000394051 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing | 0.731 |
| GLB1L | MARS2 | ENSP00000295759 | ENSP00000282276 | Beta-galactosidase-1-like protein; Probable glycosyl hydrolase | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | 0.731 |
| GLB1L | NOSTRIN | ENSP00000295759 | ENSP00000394051 | Beta-galactosidase-1-like protein; Probable glycosyl hydrolase | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing | 0.731 |
| GLB1L2 | MARS2 | ENSP00000444628 | ENSP00000282276 | Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2 | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | 0.731 |
| GLB1L2 | NOSTRIN | ENSP00000444628 | ENSP00000394051 | Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2 | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing | 0.731 |
| GLB1L3 | MARS2 | ENSP00000396615 | ENSP00000282276 | Beta-galactosidase-1-like protein 3; Galactosidase beta 1 like 3 | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | 0.731 |
| GLB1L3 | NOSTRIN | ENSP00000396615 | ENSP00000394051 | Beta-galactosidase-1-like protein 3; Galactosidase beta 1 like 3 | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing | 0.731 |
| MARS2 | GLB1 | ENSP00000282276 | ENSP00000306920 | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.731 |
| MARS2 | GLB1L | ENSP00000282276 | ENSP00000295759 | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | Beta-galactosidase-1-like protein; Probable glycosyl hydrolase | 0.731 |
