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  • 11.0 [archived version]
STRINGSTRING
PGGT1B PGGT1B NDE1 NDE1 TRIM28 TRIM28 PUS7 PUS7 ZNF655 ZNF655 PHF14 PHF14 TSC22D2 TSC22D2 PCIF1 PCIF1 PSAPL1 PSAPL1 ZNF862 ZNF862 ADAMTSL3 ADAMTSL3
"ZNF655" - Zinc finger protein 655 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
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[Homology]
Score
ZNF655Zinc finger protein 655; May be involved in transcriptional regulation; Zinc fingers C2H2-type (526 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
PSAPL1
Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids (521 aa)
           
  0.702
ZNF862
Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1169 aa)
           
  0.698
PGGT1B
Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (377 aa)
           
  0.672
TSC22D2
TSC22 domain family member 2 (780 aa)
       
 
  0.567
PCIF1
Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal domain (CTD) of RNAPII largest subunit; Protein phosphatase 1 regulatory subunits (704 aa)
           
  0.529
NDE1
Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neurona [...] (335 aa)
       
 
  0.522
PUS7
Pseudouridylate synthase 7 (661 aa)
           
  0.517
ADAMTSL3
ADAMTS-like protein 3; Immunoglobulin like domain containing (1691 aa)
           
  0.459
PHF14
PHD finger protein 14 (888 aa)
       
 
  0.455
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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