| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DGKI | ZNF506 | ENSP00000288490 | ENSP00000393835 | Diacylglycerol kinase iota; Ankyrin repeat domain containing | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.546 |
| DLEC1 | SHROOM3 | ENSP00000308597 | ENSP00000296043 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity); Belongs to the shroom family | 0.436 |
| DLEC1 | ST8SIA5 | ENSP00000308597 | ENSP00000321343 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family | 0.479 |
| DLEC1 | ZNF506 | ENSP00000308597 | ENSP00000393835 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.493 |
| PML | ZNF506 | ENSP00000268058 | ENSP00000393835 | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...] | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.402 |
| SHROOM3 | DLEC1 | ENSP00000296043 | ENSP00000308597 | Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity); Belongs to the shroom family | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | 0.436 |
| SHROOM3 | ZNF506 | ENSP00000296043 | ENSP00000393835 | Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity); Belongs to the shroom family | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.489 |
| SIRPB1 | ZNF506 | ENSP00000371018 | ENSP00000393835 | Signal-regulatory protein beta-1; Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK; C1-set domain containing | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.558 |
| SLC19A2 | ZNF506 | ENSP00000236137 | ENSP00000393835 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine; Solute carriers | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.478 |
| ST8SIA5 | DLEC1 | ENSP00000321343 | ENSP00000308597 | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | 0.479 |
| ST8SIA5 | ZNF506 | ENSP00000321343 | ENSP00000393835 | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.447 |
| TRIM28 | ZNF506 | ENSP00000253024 | ENSP00000393835 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.904 |
| ZNF506 | DGKI | ENSP00000393835 | ENSP00000288490 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Diacylglycerol kinase iota; Ankyrin repeat domain containing | 0.546 |
| ZNF506 | DLEC1 | ENSP00000393835 | ENSP00000308597 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated | 0.493 |
| ZNF506 | PML | ENSP00000393835 | ENSP00000268058 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression- activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respe [...] | 0.402 |
| ZNF506 | SHROOM3 | ENSP00000393835 | ENSP00000296043 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity); Belongs to the shroom family | 0.489 |
| ZNF506 | SIRPB1 | ENSP00000393835 | ENSP00000371018 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Signal-regulatory protein beta-1; Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK; C1-set domain containing | 0.558 |
| ZNF506 | SLC19A2 | ENSP00000393835 | ENSP00000236137 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Thiamine transporter 1; High-affinity transporter for the intake of thiamine; Solute carriers | 0.478 |
| ZNF506 | ST8SIA5 | ENSP00000393835 | ENSP00000321343 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family | 0.447 |
| ZNF506 | TRIM28 | ENSP00000393835 | ENSP00000253024 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | 0.904 |
