LHFPL3 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LHFPL3

LHFPL tetraspan subfamily member 3 (222 aa)

Predicted Functional Partners:

TSPAN4

0.745

SCP2D1

0.673

NOL4

0.610

COL11A2

0.588

NTAN1

0.577

TBCEL

0.576

PCDH15

0.570

SLC44A5

0.562

C15orf59

0.557

KIF27

0.531

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C15orf59	LHFPL3	ENSP00000457205	ENSP00000393128	UPF0583 protein C15orf59; Chromosome 15 open reading frame 59	LHFPL tetraspan subfamily member 3	0.557
COL11A2	LHFPL3	ENSP00000363840	ENSP00000393128	Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	LHFPL tetraspan subfamily member 3	0.588
KIF27	LHFPL3	ENSP00000297814	ENSP00000393128	Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins	LHFPL tetraspan subfamily member 3	0.531
KIF27	TBCEL	ENSP00000297814	ENSP00000403925	Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.583
LHFPL3	C15orf59	ENSP00000393128	ENSP00000457205	LHFPL tetraspan subfamily member 3	UPF0583 protein C15orf59; Chromosome 15 open reading frame 59	0.557
LHFPL3	COL11A2	ENSP00000393128	ENSP00000363840	LHFPL tetraspan subfamily member 3	Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens	0.588
LHFPL3	KIF27	ENSP00000393128	ENSP00000297814	LHFPL tetraspan subfamily member 3	Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins	0.531
LHFPL3	NOL4	ENSP00000393128	ENSP00000261592	LHFPL tetraspan subfamily member 3	Nucleolar protein 4	0.610
LHFPL3	NTAN1	ENSP00000393128	ENSP00000287706	LHFPL tetraspan subfamily member 3	Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme doe [...]	0.577
LHFPL3	PCDH15	ENSP00000393128	ENSP00000363068	LHFPL tetraspan subfamily member 3	Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function; Cadherin related	0.570
LHFPL3	SCP2D1	ENSP00000393128	ENSP00000366645	LHFPL tetraspan subfamily member 3	SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1	0.673
LHFPL3	SLC44A5	ENSP00000393128	ENSP00000359892	LHFPL tetraspan subfamily member 3	Choline transporter-like protein 5; Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family	0.562
LHFPL3	TBCEL	ENSP00000393128	ENSP00000403925	LHFPL tetraspan subfamily member 3	Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability	0.576
LHFPL3	TSPAN4	ENSP00000393128	ENSP00000380553	LHFPL tetraspan subfamily member 3	Tetraspanin-4; Tetraspanin 4; Belongs to the tetraspanin (TM4SF) family	0.745
NOL4	LHFPL3	ENSP00000261592	ENSP00000393128	Nucleolar protein 4	LHFPL tetraspan subfamily member 3	0.610
NTAN1	LHFPL3	ENSP00000287706	ENSP00000393128	Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme doe [...]	LHFPL tetraspan subfamily member 3	0.577
NTAN1	SCP2D1	ENSP00000287706	ENSP00000366645	Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme doe [...]	SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1	0.666
PCDH15	LHFPL3	ENSP00000363068	ENSP00000393128	Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function; Cadherin related	LHFPL tetraspan subfamily member 3	0.570
SCP2D1	LHFPL3	ENSP00000366645	ENSP00000393128	SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1	LHFPL tetraspan subfamily member 3	0.673
SCP2D1	NTAN1	ENSP00000366645	ENSP00000287706	SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1	Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N- terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme doe [...]	0.666

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About