| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AS3MT | CNNM2 | ENSP00000358896 | ENSP00000358894 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity); Belongs to the methyltransferase superfamily. Arsenite methyltransferase family | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | 0.684 |
| AS3MT | NT5C2 | ENSP00000358896 | ENSP00000339479 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity); Belongs to the methyltransferase superfamily. Arsenite methyltransferase family | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | 0.681 |
| AS3MT | POM121L2 | ENSP00000358896 | ENSP00000392726 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity); Belongs to the methyltransferase superfamily. Arsenite methyltransferase family | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | 0.660 |
| CNNM2 | AS3MT | ENSP00000358894 | ENSP00000358896 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity); Belongs to the methyltransferase superfamily. Arsenite methyltransferase family | 0.684 |
| CNNM2 | NT5C2 | ENSP00000358894 | ENSP00000339479 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | 0.747 |
| CNNM2 | POM121L2 | ENSP00000358894 | ENSP00000392726 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | 0.613 |
| NT5C2 | AS3MT | ENSP00000339479 | ENSP00000358896 | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity); Belongs to the methyltransferase superfamily. Arsenite methyltransferase family | 0.681 |
| NT5C2 | CNNM2 | ENSP00000339479 | ENSP00000358894 | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | 0.747 |
| NT5C2 | POM121L2 | ENSP00000339479 | ENSP00000392726 | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | 0.653 |
| POM121 | POM121C | ENSP00000378687 | ENSP00000481575 | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Nucleoporins | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Belongs to the POM121 family | 0.916 |
| POM121 | POM121L2 | ENSP00000378687 | ENSP00000392726 | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Nucleoporins | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | 0.800 |
| POM121C | POM121 | ENSP00000481575 | ENSP00000378687 | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Belongs to the POM121 family | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Nucleoporins | 0.916 |
| POM121C | POM121L2 | ENSP00000481575 | ENSP00000392726 | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Belongs to the POM121 family | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | 0.800 |
| POM121L2 | AS3MT | ENSP00000392726 | ENSP00000358896 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity); Belongs to the methyltransferase superfamily. Arsenite methyltransferase family | 0.660 |
| POM121L2 | CNNM2 | ENSP00000392726 | ENSP00000358894 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity) | 0.613 |
| POM121L2 | NT5C2 | ENSP00000392726 | ENSP00000339479 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Cytosolic purine 5’-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5’-monophosphate (IMP) and other purine nucleotides; 5’-nucleotidases | 0.653 |
| POM121L2 | POM121 | ENSP00000392726 | ENSP00000378687 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Nucleoporins | 0.800 |
| POM121L2 | POM121C | ENSP00000392726 | ENSP00000481575 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL); Belongs to the POM121 family | 0.800 |
| POM121L2 | PRSS16 | ENSP00000392726 | ENSP00000230582 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family | 0.558 |
| POM121L2 | SLC8A3 | ENSP00000392726 | ENSP00000370669 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family | Sodium/calcium exchanger 3; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] | 0.544 |
