AMER3 protein (human) - STRING database

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AMER3

APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity) (861 aa)

Predicted Functional Partners:

ARHGEF4

0.835

ARHGEF9

0.707

MTMR6

0.689

FRRS1L

0.642

TSGA10IP

0.640

TMEM130

0.638

FAM171B

0.633

TMEM179

0.631

TMEM145

0.631

ZNF518B

0.629

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER3	ARHGEF4	ENSP00000392700	ENSP00000316845	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing	0.835
AMER3	ARHGEF9	ENSP00000392700	ENSP00000253401	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	0.707
AMER3	FAM171B	ENSP00000392700	ENSP00000304108	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family	0.633
AMER3	FRRS1L	ENSP00000392700	ENSP00000477141	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway	0.642
AMER3	MTMR6	ENSP00000392700	ENSP00000371221	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily	0.689
AMER3	TMEM130	ENSP00000392700	ENSP00000413163	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Transmembrane protein 130	0.638
AMER3	TMEM145	ENSP00000392700	ENSP00000301204	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Transmembrane protein 145	0.631
AMER3	TMEM179	ENSP00000392700	ENSP00000450958	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Transmembrane protein 179; Belongs to the TMEM179 family	0.631
AMER3	TSGA10IP	ENSP00000392700	ENSP00000484252	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Testis specific 10 interacting protein	0.640
AMER3	ZNF518B	ENSP00000392700	ENSP00000317614	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.629
ARHGEF4	AMER3	ENSP00000316845	ENSP00000392700	Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	0.835
ARHGEF4	MTMR6	ENSP00000316845	ENSP00000371221	Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing	Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily	0.672
ARHGEF9	AMER3	ENSP00000253401	ENSP00000392700	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	0.707
ARHGEF9	MTMR6	ENSP00000253401	ENSP00000371221	Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing	Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily	0.663
FAM171B	AMER3	ENSP00000304108	ENSP00000392700	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	0.633
FAM171B	TMEM130	ENSP00000304108	ENSP00000413163	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family	Transmembrane protein 130	0.674
FAM171B	TMEM145	ENSP00000304108	ENSP00000301204	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family	Transmembrane protein 145	0.631
FAM171B	TMEM179	ENSP00000304108	ENSP00000450958	Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family	Transmembrane protein 179; Belongs to the TMEM179 family	0.642
FRRS1L	AMER3	ENSP00000477141	ENSP00000392700	DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway	APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	0.642
FRRS1L	TMEM130	ENSP00000477141	ENSP00000413163	DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway	Transmembrane protein 130	0.516

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