| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKIRIN1 | AKIRIN2 | ENSP00000392678 | ENSP00000257787 | Akirin-1; Akirin 1 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | 0.870 |
| AKIRIN1 | GABRR1 | ENSP00000392678 | ENSP00000412673 | Akirin-1; Akirin 1 | Gamma-aminobutyric acid receptor subunit rho-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission; Gamma-aminobutyric acid type A receptor subunits | 0.625 |
| AKIRIN1 | GJB7 | ENSP00000392678 | ENSP00000435355 | Akirin-1; Akirin 1 | Gap junction beta-7 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Beta-type (group I) subfamily | 0.596 |
| AKIRIN1 | MANEAL | ENSP00000392678 | ENSP00000362136 | Akirin-1; Akirin 1 | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family | 0.623 |
| AKIRIN1 | MSTN | ENSP00000392678 | ENSP00000260950 | Akirin-1; Akirin 1 | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family | 0.667 |
| AKIRIN1 | RAN | ENSP00000392678 | ENSP00000446215 | Akirin-1; Akirin 1 | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment a [...] | 0.719 |
| AKIRIN1 | RARS2 | ENSP00000392678 | ENSP00000358549 | Akirin-1; Akirin 1 | Probable arginine--tRNA ligase, mitochondrial; arginyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | 0.610 |
| AKIRIN1 | RNGTT | ENSP00000392678 | ENSP00000358497 | Akirin-1; Akirin 1 | mRNA-capping enzyme; Bifunctional mRNA-capping enzyme exhibiting RNA 5’- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation- by removing the gamma-phosphate from the 5’-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5’-diphosphate terminus | 0.608 |
| AKIRIN1 | WDR13 | ENSP00000392678 | ENSP00000365919 | Akirin-1; Akirin 1 | WD repeat-containing protein 13; WD repeat domain containing | 0.712 |
| AKIRIN1 | ZNF292 | ENSP00000392678 | ENSP00000358590 | Akirin-1; Akirin 1 | Zinc finger protein 292; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.640 |
| AKIRIN2 | AKIRIN1 | ENSP00000257787 | ENSP00000392678 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | Akirin-1; Akirin 1 | 0.870 |
| AKIRIN2 | GABRR1 | ENSP00000257787 | ENSP00000412673 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | Gamma-aminobutyric acid receptor subunit rho-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission; Gamma-aminobutyric acid type A receptor subunits | 0.609 |
| AKIRIN2 | GJB7 | ENSP00000257787 | ENSP00000435355 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | Gap junction beta-7 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Beta-type (group I) subfamily | 0.607 |
| AKIRIN2 | MANEAL | ENSP00000257787 | ENSP00000362136 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family | 0.601 |
| AKIRIN2 | RAN | ENSP00000257787 | ENSP00000446215 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment a [...] | 0.770 |
| AKIRIN2 | RARS2 | ENSP00000257787 | ENSP00000358549 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | Probable arginine--tRNA ligase, mitochondrial; arginyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I | 0.657 |
| AKIRIN2 | RNGTT | ENSP00000257787 | ENSP00000358497 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | mRNA-capping enzyme; Bifunctional mRNA-capping enzyme exhibiting RNA 5’- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation- by removing the gamma-phosphate from the 5’-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5’-diphosphate terminus | 0.595 |
| AKIRIN2 | ZNF292 | ENSP00000257787 | ENSP00000358590 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | Zinc finger protein 292; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.699 |
| GABRR1 | AKIRIN1 | ENSP00000412673 | ENSP00000392678 | Gamma-aminobutyric acid receptor subunit rho-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission; Gamma-aminobutyric acid type A receptor subunits | Akirin-1; Akirin 1 | 0.625 |
| GABRR1 | AKIRIN2 | ENSP00000412673 | ENSP00000257787 | Gamma-aminobutyric acid receptor subunit rho-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission; Gamma-aminobutyric acid type A receptor subunits | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity); Belongs to the akirin family | 0.609 |
