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STRINGSTRING
ARL4A ARL4A PHLPP2 PHLPP2 TOM1L2 TOM1L2 MPPE1 MPPE1 MAST2 MAST2 ZNF488 ZNF488 WDR33 WDR33 ZNF487 ZNF487 TSPAN33 TSPAN33 RHOT1 RHOT1 SIGLEC10 SIGLEC10
"ZNF487" - Putative zinc finger protein 487 in Homo sapiens
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ZNF487Putative zinc finger protein 487; May be involved in transcriptional regulation; Zinc fingers C2H2-type (208 aa)    
Predicted Functional Partners:
ZNF488
Zinc finger protein 488; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (340 aa)
            
  0.552
MPPE1
Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins; Belongs to the metallophosphoesterase superfamily. MPPE1 family (396 aa)
            
  0.541
TOM1L2
TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling (507 aa)
        
 
  0.529
ARL4A
ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form; ARF GTPase family (200 aa)
        
 
  0.496
WDR33
pre-mRNA 3’ end processing protein WDR33; Essential for both cleavage and polyadenylation of pre- mRNA 3’ ends; WD repeat domain containing (1336 aa)
        
 
  0.495
MAST2
Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity); PDZ domain containing (1798 aa)
      
   
  0.447
SIGLEC10
Sialic acid-binding Ig-like lectin 10; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative re [...] (697 aa)
            
  0.445
TSPAN33
Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity; Belongs to the tetraspanin (TM4SF) family (283 aa)
            
  0.444
RHOT1
Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution; EF-hand domain containing (691 aa)
        
 
  0.424
PHLPP2
PH domain leucine-rich repeat-containing protein phosphatase 2; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser-657’ of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser- 473’ of Akt triggers apopt [...] (1323 aa)
      
 
  0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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