| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAD8 | MTMR11 | ENSP00000281182 | ENSP00000391668 | Isobutyryl-CoA dehydrogenase, mitochondrial; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex; Acyl-CoA dehydrogenase family | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | 0.504 |
| ACAD8 | OTUD7B | ENSP00000281182 | ENSP00000462729 | Isobutyryl-CoA dehydrogenase, mitochondrial; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex; Acyl-CoA dehydrogenase family | OTU domain-containing protein 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that le [...] | 0.404 |
| ACAD8 | SKIV2L | ENSP00000281182 | ENSP00000364543 | Isobutyryl-CoA dehydrogenase, mitochondrial; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex; Acyl-CoA dehydrogenase family | Helicase SKI2W; Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C); Belongs to the helicase family. SKI2 subfamily | 0.473 |
| DUSP10 | MTMR11 | ENSP00000355866 | ENSP00000391668 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | 0.410 |
| KIAA1456 | MTMR11 | ENSP00000432695 | ENSP00000391668 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | 0.403 |
| KIAA1456 | OR10H2 | ENSP00000432695 | ENSP00000306095 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | 0.669 |
| KIAA1456 | ZNF212 | ENSP00000432695 | ENSP00000338572 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.465 |
| MTMR11 | ACAD8 | ENSP00000391668 | ENSP00000281182 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Isobutyryl-CoA dehydrogenase, mitochondrial; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex; Acyl-CoA dehydrogenase family | 0.504 |
| MTMR11 | DUSP10 | ENSP00000391668 | ENSP00000355866 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38 | 0.410 |
| MTMR11 | KIAA1456 | ENSP00000391668 | ENSP00000432695 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | 0.403 |
| MTMR11 | OR10H2 | ENSP00000391668 | ENSP00000306095 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | 0.630 |
| MTMR11 | OTUD7B | ENSP00000391668 | ENSP00000462729 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | OTU domain-containing protein 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that le [...] | 0.400 |
| MTMR11 | POLD4 | ENSP00000391668 | ENSP00000311368 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | DNA polymerase delta subunit 4; As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3’ to 5’ exonuclease activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of DNA replication stress, required for the repair of broken replication forks through break- induced replication (B [...] | 0.416 |
| MTMR11 | SKIV2L | ENSP00000391668 | ENSP00000364543 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Helicase SKI2W; Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C); Belongs to the helicase family. SKI2 subfamily | 0.423 |
| MTMR11 | TMEM205 | ENSP00000391668 | ENSP00000346954 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin | 0.512 |
| MTMR11 | ZNF212 | ENSP00000391668 | ENSP00000338572 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.427 |
| OR10H2 | KIAA1456 | ENSP00000306095 | ENSP00000432695 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | 0.669 |
| OR10H2 | MTMR11 | ENSP00000306095 | ENSP00000391668 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins | 0.630 |
| OR10H2 | ZNF212 | ENSP00000306095 | ENSP00000338572 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.670 |
| OTUD7B | ACAD8 | ENSP00000462729 | ENSP00000281182 | OTU domain-containing protein 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that le [...] | Isobutyryl-CoA dehydrogenase, mitochondrial; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex; Acyl-CoA dehydrogenase family | 0.404 |
