node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000235718 | NR2E3 | ENSP00000391664 | ENSP00000482504 | Membrane frizzled-related protein; May play a role in eye development | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | 0.644 |
ENSG00000235718 | PRPH2 | ENSP00000391664 | ENSP00000230381 | Membrane frizzled-related protein; May play a role in eye development | Peripherin-2; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis; Belongs to the PRPH2/ROM1 family | 0.671 |
ENSG00000235718 | PRSS56 | ENSP00000391664 | ENSP00000479745 | Membrane frizzled-related protein; May play a role in eye development | Serine protease 56; Serine protease required during eye development | 0.796 |
ENSG00000235718 | RD3 | ENSP00000391664 | ENSP00000355969 | Membrane frizzled-related protein; May play a role in eye development | Protein RD3; Retinal degeneration 3 | 0.714 |
ENSG00000235718 | VSX2 | ENSP00000391664 | ENSP00000261980 | Membrane frizzled-related protein; May play a role in eye development | Visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family | 0.658 |
ENSG00000235718 | WNT10A | ENSP00000391664 | ENSP00000258411 | Membrane frizzled-related protein; May play a role in eye development | Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters; Belongs to the Wnt family | 0.646 |
ENSG00000235718 | WNT5B | ENSP00000391664 | ENSP00000380379 | Membrane frizzled-related protein; May play a role in eye development | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family | 0.646 |
ENSG00000235718 | WNT8A | ENSP00000391664 | ENSP00000426653 | Membrane frizzled-related protein; May play a role in eye development | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.659 |
ENSG00000235718 | WNT8B | ENSP00000391664 | ENSP00000340677 | Membrane frizzled-related protein; May play a role in eye development | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus | 0.655 |
ENSG00000235718 | WNT9B | ENSP00000391664 | ENSP00000290015 | Membrane frizzled-related protein; May play a role in eye development | Protein Wnt-9b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity) | 0.655 |
NR2E3 | ENSG00000235718 | ENSP00000482504 | ENSP00000391664 | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | Membrane frizzled-related protein; May play a role in eye development | 0.644 |
NR2E3 | PRPH2 | ENSP00000482504 | ENSP00000230381 | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | Peripherin-2; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis; Belongs to the PRPH2/ROM1 family | 0.676 |
NR2E3 | RD3 | ENSP00000482504 | ENSP00000355969 | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | Protein RD3; Retinal degeneration 3 | 0.583 |
NR2E3 | VSX2 | ENSP00000482504 | ENSP00000261980 | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | Visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family | 0.682 |
PRPH2 | ENSG00000235718 | ENSP00000230381 | ENSP00000391664 | Peripherin-2; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis; Belongs to the PRPH2/ROM1 family | Membrane frizzled-related protein; May play a role in eye development | 0.671 |
PRPH2 | NR2E3 | ENSP00000230381 | ENSP00000482504 | Peripherin-2; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis; Belongs to the PRPH2/ROM1 family | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | 0.676 |
PRPH2 | RD3 | ENSP00000230381 | ENSP00000355969 | Peripherin-2; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis; Belongs to the PRPH2/ROM1 family | Protein RD3; Retinal degeneration 3 | 0.862 |
PRSS56 | ENSG00000235718 | ENSP00000479745 | ENSP00000391664 | Serine protease 56; Serine protease required during eye development | Membrane frizzled-related protein; May play a role in eye development | 0.796 |
RD3 | ENSG00000235718 | ENSP00000355969 | ENSP00000391664 | Protein RD3; Retinal degeneration 3 | Membrane frizzled-related protein; May play a role in eye development | 0.714 |
RD3 | NR2E3 | ENSP00000355969 | ENSP00000482504 | Protein RD3; Retinal degeneration 3 | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression; Nuclear hormone receptors | 0.583 |