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  • 11.0 [archived version]
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TACC2 TACC2 TRIOBP TRIOBP TMCO1 TMCO1 UBTF UBTF ZNF780B ZNF780B C19orf47 C19orf47 ASB16 ASB16 TTC9B TTC9B TIGD2 TIGD2 C19orf54 C19orf54 TMEM91 TMEM91
"ZNF780B" - Zinc finger protein 780B in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF780BZinc finger protein 780B; May be involved in transcriptional regulation; Zinc fingers C2H2-type (833 aa)    
Predicted Functional Partners:
TACC2
Transforming acidic coiled-coil-containing protein 2; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker (2948 aa)
       
 
  0.732
TRIOBP
TRIO and F-actin-binding protein; May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover; Deafness associated genes (2365 aa)
           
  0.731
UBTF
Nucleolar transcription factor 1; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element (764 aa)
       
 
  0.649
TMCO1
Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (239 aa)
           
  0.553
ASB16
Ankyrin repeat and SOCS box protein 16; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family (453 aa)
     
 
  0.541
C19orf47
Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47 (422 aa)
           
  0.529
TIGD2
Tigger transposable element-derived protein 2; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes (525 aa)
       
 
  0.514
C19orf54
UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family (351 aa)
           
  0.511
TMEM91
Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family (172 aa)
           
  0.473
TTC9B
Tetratricopeptide repeat domain containing (239 aa)
           
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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