PEX5 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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PEX5

Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (660 aa)

Predicted Functional Partners:

PEX14

0.999

PEX7

0.998

PEX13

0.991

SCP2

0.990

PEX12

0.988

PEX6

0.969

PEX3

0.967

PEX10

0.966

PEX2

0.962

AGXT

0.952

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	PEX10	ENSP00000302620	ENSP00000288774	Alanine-glyoxylate aminotransferase	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	0.927
AGXT	PEX12	ENSP00000302620	ENSP00000482609	Alanine-glyoxylate aminotransferase	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	0.926
AGXT	PEX13	ENSP00000302620	ENSP00000295030	Alanine-glyoxylate aminotransferase	Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins	0.925
AGXT	PEX14	ENSP00000302620	ENSP00000349016	Alanine-glyoxylate aminotransferase	Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins	0.924
AGXT	PEX2	ENSP00000302620	ENSP00000349543	Alanine-glyoxylate aminotransferase	Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family	0.924
AGXT	PEX3	ENSP00000302620	ENSP00000356563	Alanine-glyoxylate aminotransferase	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family	0.546
AGXT	PEX5	ENSP00000302620	ENSP00000391601	Alanine-glyoxylate aminotransferase	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.952
AGXT	SCP2	ENSP00000302620	ENSP00000360569	Alanine-glyoxylate aminotransferase	Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis	0.932
PEX10	AGXT	ENSP00000288774	ENSP00000302620	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Alanine-glyoxylate aminotransferase	0.927
PEX10	PEX12	ENSP00000288774	ENSP00000482609	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	0.999
PEX10	PEX13	ENSP00000288774	ENSP00000295030	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins; Peroxins	0.996
PEX10	PEX14	ENSP00000288774	ENSP00000349016	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin; Peroxins	0.992
PEX10	PEX2	ENSP00000288774	ENSP00000349543	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family	0.999
PEX10	PEX3	ENSP00000288774	ENSP00000356563	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family	0.941
PEX10	PEX5	ENSP00000288774	ENSP00000391601	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	0.966
PEX10	PEX6	ENSP00000288774	ENSP00000303511	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.995
PEX10	PEX7	ENSP00000288774	ENSP00000315680	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin-7 family	0.996
PEX10	SCP2	ENSP00000288774	ENSP00000360569	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis	0.931
PEX12	AGXT	ENSP00000482609	ENSP00000302620	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Alanine-glyoxylate aminotransferase	0.926
PEX12	PEX10	ENSP00000482609	ENSP00000288774	Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins	Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins	0.999

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