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  • 11.0 [archived version]
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TRABD TRABD PPP6R2 PPP6R2 KIAA1147 KIAA1147 DENND6B DENND6B FAM45A FAM45A CHML CHML GDI1 GDI1 GDI2 GDI2 AVL9 AVL9 RAB14 RAB14 CHM CHM
"DENND6B" - Protein DENND6B in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DENND6BProtein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing (585 aa)    
Predicted Functional Partners:
GDI1
Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes (447 aa)
     
 
  0.905
GDI2
Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (445 aa)
     
 
  0.903
CHML
Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family (656 aa)
     
 
    0.902
CHM
Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative [...] (653 aa)
     
 
    0.902
RAB14
Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 s [...] (215 aa)
     
 
    0.901
FAM45A
Protein FAM45A; Family with sequence similarity 45 member A (357 aa)
     
   
  0.743
KIAA1147
Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (455 aa)
           
  0.710
AVL9
Late secretory pathway protein AVL9 homolog; Functions in cell migration (648 aa)
           
  0.622
PPP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha; Belongs to the SAPS family (959 aa)
     
   
  0.594
TRABD
TraB domain-containing protein; TraB domain containing (376 aa)
     
   
  0.567
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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