• Version:
  • 11.0 [archived version]
STRINGSTRING
INS INS KCNRG KCNRG KCTD18 KCTD18 KCNK16 KCNK16 GCC1 GCC1 PSMD6 PSMD6 SLC24A3 SLC24A3 R3HDML R3HDML ZFAND3 ZFAND3 RIN2 RIN2 FITM2 FITM2
"KCNK16" - Potassium channel subfamily K member 16 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
KCNK16Potassium channel subfamily K member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel subfamily K (322 aa)    
Predicted Functional Partners:
INS
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (110 aa)
     
   
  0.680
ZFAND3
Zinc finger AN1-type containing 3 (227 aa)
           
  0.674
R3HDML
Peptidase inhibitor R3HDML; Putative serine protease inhibitor; CAP superfamily (253 aa)
           
  0.673
GCC1
GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure (775 aa)
           
  0.669
FITM2
Fat storage-inducing transmembrane protein 2; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization (262 aa)
           
  0.649
KCNRG
Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes (272 aa)
           
  0.612
KCTD18
BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 (426 aa)
           
  0.598
RIN2
Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP; Belongs to the RIN (Ras interaction/interference) family (944 aa)
           
  0.590
SLC24A3
Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers (644 aa)
     
   
  0.589
PSMD6
Proteasome 26S subunit, non-ATPase 6 (442 aa)
           
  0.585
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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