| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ELAVL1 | HNRNPD | ENSP00000385269 | ENSP00000313199 | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | 0.947 |
| ELAVL1 | KHSRP | ENSP00000385269 | ENSP00000381216 | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | 0.936 |
| ELAVL1 | TIAL1 | ENSP00000385269 | ENSP00000358089 | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | Nucleolysin TIAR; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis | 0.700 |
| ELAVL1 | ZFP36 | ENSP00000385269 | ENSP00000469647 | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3’-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compone [...] | 0.799 |
| ELAVL1 | ZNF692 | ENSP00000385269 | ENSP00000391200 | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.645 |
| HNRNPD | ELAVL1 | ENSP00000313199 | ENSP00000385269 | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | 0.947 |
| HNRNPD | KHSRP | ENSP00000313199 | ENSP00000381216 | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | 0.849 |
| HNRNPD | TIAL1 | ENSP00000313199 | ENSP00000358089 | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | Nucleolysin TIAR; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis | 0.534 |
| HNRNPD | ZFP36 | ENSP00000313199 | ENSP00000469647 | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3’-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compone [...] | 0.765 |
| HNRNPD | ZNF692 | ENSP00000313199 | ENSP00000391200 | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.676 |
| IL4I1 | PCK2 | ENSP00000472474 | ENSP00000216780 | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family | 0.809 |
| IL4I1 | ZNF692 | ENSP00000472474 | ENSP00000391200 | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.513 |
| KHSRP | ELAVL1 | ENSP00000381216 | ENSP00000385269 | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | ELAV-like protein 1; RNA-binding protein that binds to the 3’-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation- preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3’-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUU [...] | 0.936 |
| KHSRP | HNRNPD | ENSP00000381216 | ENSP00000313199 | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3’-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5’-UUAG-3’ sequence and also weaker to the single-stranded 5’-TTAGGG-3’ telomeric DNA repeat. Binds RNA oligonucleotides with 5’-UUAGGG-3’ repeats more tightly than the telomeric single-s [...] | 0.849 |
| KHSRP | TIAL1 | ENSP00000381216 | ENSP00000358089 | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | Nucleolysin TIAR; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis | 0.783 |
| KHSRP | ZFP36 | ENSP00000381216 | ENSP00000469647 | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3’-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compone [...] | 0.829 |
| KHSRP | ZNF692 | ENSP00000381216 | ENSP00000391200 | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3’- UTR, possibly by recruiting degradation machine [...] | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.675 |
| OSBPL6 | ZNF692 | ENSP00000376293 | ENSP00000391200 | Oxysterol-binding protein-related protein 6; Weakly binds 25-hydroxycholesterol; Belongs to the OSBP family | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.544 |
| PCK2 | IL4I1 | ENSP00000216780 | ENSP00000472474 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs to the flavin monoamine oxidase family. FIG1 subfamily | 0.809 |
| PCK2 | ZNF692 | ENSP00000216780 | ENSP00000391200 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.552 |
