node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTBL2 | LETMD1 | ENSP00000416706 | ENSP00000389903 | Beta-actin-like protein 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.506 |
CXXC5 | LETMD1 | ENSP00000302543 | ENSP00000389903 | CXXC-type zinc finger protein 5; May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and [...] | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.604 |
CXXC5 | TMEM74 | ENSP00000302543 | ENSP00000297459 | CXXC-type zinc finger protein 5; May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and [...] | Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction; Belongs to the TMEM74 family | 0.523 |
LETMD1 | ACTBL2 | ENSP00000389903 | ENSP00000416706 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Beta-actin-like protein 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.506 |
LETMD1 | CXXC5 | ENSP00000389903 | ENSP00000302543 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | CXXC-type zinc finger protein 5; May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and [...] | 0.604 |
LETMD1 | LMBR1 | ENSP00000389903 | ENSP00000326604 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Limb region 1 protein homolog; Putative membrane receptor | 0.497 |
LETMD1 | PPAP2B | ENSP00000389903 | ENSP00000360296 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Phospholipid phosphatase 3; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions | 0.625 |
LETMD1 | REEP5 | ENSP00000389903 | ENSP00000368959 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family | 0.709 |
LETMD1 | RPL14 | ENSP00000389903 | ENSP00000379506 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 60S ribosomal protein L14; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL14 family | 0.524 |
LETMD1 | TEX35 | ENSP00000389903 | ENSP00000323795 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Testis-expressed protein 35; Testis expressed 35 | 0.517 |
LETMD1 | TMEM74 | ENSP00000389903 | ENSP00000297459 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction; Belongs to the TMEM74 family | 0.732 |
LETMD1 | TNFAIP1 | ENSP00000389903 | ENSP00000226225 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity; Belongs to the BACURD family | 0.609 |
LETMD1 | UBXN1 | ENSP00000389903 | ENSP00000294119 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] | 0.571 |
LMBR1 | LETMD1 | ENSP00000326604 | ENSP00000389903 | Limb region 1 protein homolog; Putative membrane receptor | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.497 |
PPAP2B | LETMD1 | ENSP00000360296 | ENSP00000389903 | Phospholipid phosphatase 3; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.625 |
PPAP2B | TMEM74 | ENSP00000360296 | ENSP00000297459 | Phospholipid phosphatase 3; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions | Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction; Belongs to the TMEM74 family | 0.520 |
PPAP2B | UBXN1 | ENSP00000360296 | ENSP00000294119 | Phospholipid phosphatase 3; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] | 0.467 |
REEP5 | LETMD1 | ENSP00000368959 | ENSP00000389903 | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.709 |
RPL14 | LETMD1 | ENSP00000379506 | ENSP00000389903 | 60S ribosomal protein L14; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL14 family | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.524 |
TEX35 | LETMD1 | ENSP00000323795 | ENSP00000389903 | Testis-expressed protein 35; Testis expressed 35 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers | 0.517 |