| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMMECR1 | C5orf15 | ENSP00000262844 | ENSP00000231512 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 | 0.534 |
| AMMECR1 | TMCO3 | ENSP00000262844 | ENSP00000389399 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.637 |
| AMMECR1 | TMTC4 | ENSP00000262844 | ENSP00000343871 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family | 0.548 |
| C5orf15 | AMMECR1 | ENSP00000231512 | ENSP00000262844 | Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.534 |
| C5orf15 | TMCO3 | ENSP00000231512 | ENSP00000389399 | Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.637 |
| C5orf15 | TMTC4 | ENSP00000231512 | ENSP00000343871 | Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family | 0.563 |
| HSPA9 | TMCO3 | ENSP00000297185 | ENSP00000389399 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.543 |
| KDELC1 | TMCO3 | ENSP00000365172 | ENSP00000389399 | KDEL motif-containing protein 1; Glycosyltransferase family 90; Belongs to the KDELC family | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.540 |
| MARCH4 | TMCO3 | ENSP00000273067 | ENSP00000389399 | E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.536 |
| MARCH4 | TMEM106C | ENSP00000273067 | ENSP00000400471 | E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | Transmembrane protein 106C | 0.539 |
| MARCH4 | TMEM117 | ENSP00000273067 | ENSP00000266534 | E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway | 0.664 |
| SLC9A7 | TMCO3 | ENSP00000480916 | ENSP00000389399 | Sodium/hydrogen exchanger 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis; Solute carriers | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.535 |
| SLC9A8 | TMCO3 | ENSP00000416418 | ENSP00000389399 | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | 0.535 |
| TMCO3 | AMMECR1 | ENSP00000389399 | ENSP00000262844 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 | 0.637 |
| TMCO3 | C5orf15 | ENSP00000389399 | ENSP00000231512 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 | 0.637 |
| TMCO3 | HSPA9 | ENSP00000389399 | ENSP00000297185 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging (By similarity); Belongs to the heat shock protein 70 family | 0.543 |
| TMCO3 | KDELC1 | ENSP00000389399 | ENSP00000365172 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | KDEL motif-containing protein 1; Glycosyltransferase family 90; Belongs to the KDELC family | 0.540 |
| TMCO3 | MARCH4 | ENSP00000389399 | ENSP00000273067 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers | 0.536 |
| TMCO3 | SLC9A7 | ENSP00000389399 | ENSP00000480916 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | Sodium/hydrogen exchanger 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis; Solute carriers | 0.535 |
| TMCO3 | SLC9A8 | ENSP00000389399 | ENSP00000416418 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation-proton antiporter 2 (CPA2) transporter (TC 2.A.37) family | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation-proton antiporter 1 (CPA1) transporter (TC 2.A.36) family | 0.535 |
