node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY1 | C17orf62 | ENSP00000385887 | ENSP00000388909 | Ankyrin repeat and MYND domain containing 1 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.692 |
C17orf62 | ANKMY1 | ENSP00000388909 | ENSP00000385887 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Ankyrin repeat and MYND domain containing 1 | 0.692 |
C17orf62 | DHRS7 | ENSP00000388909 | ENSP00000216500 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | 0.716 |
C17orf62 | POPDC2 | ENSP00000388909 | ENSP00000264231 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | 0.536 |
C17orf62 | TMEM126A | ENSP00000388909 | ENSP00000306887 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 126A; Belongs to the TMEM126 family | 0.765 |
C17orf62 | TMEM199 | ENSP00000388909 | ENSP00000292114 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.730 |
C17orf62 | TMEM201 | ENSP00000388909 | ENSP00000344503 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery | 0.555 |
C17orf62 | TMEM209 | ENSP00000388909 | ENSP00000380747 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 209 | 0.668 |
C17orf62 | TMEM38A | ENSP00000388909 | ENSP00000187762 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores | 0.709 |
C17orf62 | TMEM41A | ENSP00000388909 | ENSP00000406885 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane protein 41A; Belongs to the TMEM41 family | 0.715 |
C17orf62 | TMTC3 | ENSP00000388909 | ENSP00000266712 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.621 |
DHRS7 | C17orf62 | ENSP00000216500 | ENSP00000388909 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.716 |
DHRS7 | POPDC2 | ENSP00000216500 | ENSP00000264231 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | 0.598 |
DHRS7 | TMEM126A | ENSP00000216500 | ENSP00000306887 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 126A; Belongs to the TMEM126 family | 0.746 |
DHRS7 | TMEM199 | ENSP00000216500 | ENSP00000292114 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis | 0.559 |
DHRS7 | TMEM201 | ENSP00000216500 | ENSP00000344503 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery | 0.565 |
DHRS7 | TMEM209 | ENSP00000216500 | ENSP00000380747 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane protein 209 | 0.501 |
DHRS7 | TMEM38A | ENSP00000216500 | ENSP00000187762 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores | 0.762 |
DHRS7 | TMTC3 | ENSP00000216500 | ENSP00000266712 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; Tetratricopeptide repeat domain containing | 0.646 |
POPDC2 | C17orf62 | ENSP00000264231 | ENSP00000388909 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density; Belongs to the popeye family | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 | 0.536 |