• Version:
  • 11.0 [archived version]
STRINGSTRING
PRPF31 PRPF31 SMYD4 SMYD4 TBC1D9 TBC1D9 ROGDI ROGDI SDF4 SDF4 STK11IP STK11IP LANCL1 LANCL1 STOM STOM KANSL1L KANSL1L EPS8 EPS8 MYO7A MYO7A
"LANCL1" - LanC-like protein 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
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Experiments
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[Homology]
Score
LANCL1LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione (399 aa)    
Predicted Functional Partners:
STOM
Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family (288 aa)
       
 
  0.838
TBC1D9
TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing (1266 aa)
       
      0.692
EPS8
Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] (822 aa)
           
  0.647
SDF4
45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family (362 aa)
           
  0.643
STK11IP
Serine/threonine-protein kinase 11-interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization (1099 aa)
           
  0.626
KANSL1L
KAT8 regulatory NSL complex subunit 1 like (987 aa)
           
  0.599
ROGDI
Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family (287 aa)
           
  0.587
PRPF31
U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein (499 aa)
           
  0.583
SMYD4
SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily (804 aa)
     
   
  0.575
MYO7A
Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] (2215 aa)
     
 
  0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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