node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPS8 | LANCL1 | ENSP00000281172 | ENSP00000388713 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.647 |
EPS8 | MYO7A | ENSP00000281172 | ENSP00000386331 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] | Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] | 0.458 |
KANSL1L | LANCL1 | ENSP00000281772 | ENSP00000388713 | KAT8 regulatory NSL complex subunit 1 like | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.599 |
LANCL1 | EPS8 | ENSP00000388713 | ENSP00000281172 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] | 0.647 |
LANCL1 | KANSL1L | ENSP00000388713 | ENSP00000281772 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | KAT8 regulatory NSL complex subunit 1 like | 0.599 |
LANCL1 | MYO7A | ENSP00000388713 | ENSP00000386331 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] | 0.560 |
LANCL1 | PRPF31 | ENSP00000388713 | ENSP00000324122 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.583 |
LANCL1 | ROGDI | ENSP00000388713 | ENSP00000322832 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.587 |
LANCL1 | SDF4 | ENSP00000388713 | ENSP00000353094 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family | 0.643 |
LANCL1 | SMYD4 | ENSP00000388713 | ENSP00000304360 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.575 |
LANCL1 | STK11IP | ENSP00000388713 | ENSP00000295641 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Serine/threonine-protein kinase 11-interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization | 0.626 |
LANCL1 | STOM | ENSP00000388713 | ENSP00000286713 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family | 0.838 |
LANCL1 | TBC1D9 | ENSP00000388713 | ENSP00000411197 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing | 0.692 |
MYO7A | EPS8 | ENSP00000386331 | ENSP00000281172 | Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and act [...] | 0.458 |
MYO7A | LANCL1 | ENSP00000386331 | ENSP00000388713 | Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differenti [...] | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.560 |
PRPF31 | LANCL1 | ENSP00000324122 | ENSP00000388713 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.583 |
PRPF31 | ROGDI | ENSP00000324122 | ENSP00000322832 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | 0.562 |
PRPF31 | SMYD4 | ENSP00000324122 | ENSP00000304360 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.592 |
ROGDI | LANCL1 | ENSP00000322832 | ENSP00000388713 | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione | 0.587 |
ROGDI | PRPF31 | ENSP00000322832 | ENSP00000324122 | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonucleoprotein | 0.562 |