| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP14 | MPPED1 | ENSP00000360485 | ENSP00000388137 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | 0.660 |
| AKAP14 | PKIB | ENSP00000360485 | ENSP00000480824 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains | 0.608 |
| AKAP14 | SLAIN2 | ENSP00000360485 | ENSP00000264313 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase | 0.634 |
| MPPED1 | AKAP14 | ENSP00000388137 | ENSP00000360485 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins | 0.660 |
| MPPED1 | MPPED2 | ENSP00000388137 | ENSP00000350833 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity); Belongs to the UPF0046 family | 0.742 |
| MPPED1 | NR2F6 | ENSP00000388137 | ENSP00000291442 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] | 0.729 |
| MPPED1 | PHKA1 | ENSP00000388137 | ENSP00000362643 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin | 0.773 |
| MPPED1 | PHKA2 | ENSP00000388137 | ENSP00000369274 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin | 0.702 |
| MPPED1 | PKIB | ENSP00000388137 | ENSP00000480824 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains | 0.644 |
| MPPED1 | SLAIN2 | ENSP00000388137 | ENSP00000264313 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase | 0.653 |
| MPPED1 | SULT4A1 | ENSP00000388137 | ENSP00000332565 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3’-phospho-5’-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS; Sulfotransferases, cytosolic | 0.792 |
| MPPED1 | UCK1 | ENSP00000388137 | ENSP00000361285 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Uridine-cytidine kinase 1; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine | 0.735 |
| MPPED1 | UPRT | ENSP00000388137 | ENSP00000362481 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | Uracil phosphoribosyltransferase homolog; Belongs to the UPRTase family | 0.686 |
| MPPED2 | MPPED1 | ENSP00000350833 | ENSP00000388137 | Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity); Belongs to the UPF0046 family | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | 0.742 |
| MPPED2 | NR2F6 | ENSP00000350833 | ENSP00000291442 | Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity); Belongs to the UPF0046 family | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] | 0.866 |
| NR2F6 | MPPED1 | ENSP00000291442 | ENSP00000388137 | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | 0.729 |
| NR2F6 | MPPED2 | ENSP00000291442 | ENSP00000350833 | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcription [...] | Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity); Belongs to the UPF0046 family | 0.866 |
| PHKA1 | MPPED1 | ENSP00000362643 | ENSP00000388137 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | 0.773 |
| PHKA1 | PHKA2 | ENSP00000362643 | ENSP00000369274 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin | Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin | 0.806 |
| PHKA2 | MPPED1 | ENSP00000369274 | ENSP00000388137 | Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) | 0.702 |
