node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2CD4C | ELFN2 | ENSP00000328677 | ENSP00000385277 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.623 |
C2CD4C | HIC2 | ENSP00000328677 | ENSP00000387757 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.503 |
CCDC61 | HIC2 | ENSP00000471454 | ENSP00000387757 | Coiled-coil domain containing 61 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.473 |
DUSP5 | HIC2 | ENSP00000358596 | ENSP00000387757 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.563 |
ELFN2 | C2CD4C | ENSP00000385277 | ENSP00000328677 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | 0.623 |
ELFN2 | HIC2 | ENSP00000385277 | ENSP00000387757 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.496 |
FOXD4L4 | HIC2 | ENSP00000366630 | ENSP00000387757 | Forkhead box D4 like 4 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.486 |
HIC2 | C2CD4C | ENSP00000387757 | ENSP00000328677 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family | 0.503 |
HIC2 | CCDC61 | ENSP00000387757 | ENSP00000471454 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Coiled-coil domain containing 61 | 0.473 |
HIC2 | DUSP5 | ENSP00000387757 | ENSP00000358596 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1; MAP kinase phosphatases | 0.563 |
HIC2 | ELFN2 | ENSP00000387757 | ENSP00000385277 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.496 |
HIC2 | FOXD4L4 | ENSP00000387757 | ENSP00000366630 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Forkhead box D4 like 4 | 0.486 |
HIC2 | KCNU1 | ENSP00000387757 | ENSP00000382770 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina; Belongs to the potassium channel family. Calcium- a [...] | 0.459 |
HIC2 | MBD6 | ENSP00000387757 | ENSP00000347896 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Methyl-CpG-binding domain protein 6; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro); Methyl-CpG binding domain containing | 0.615 |
HIC2 | PHF2 | ENSP00000387757 | ENSP00000352185 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Lysine-specific demethylase PHF2; Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA- forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated ’Lys-9’ of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethyl [...] | 0.445 |
HIC2 | RNF44 | ENSP00000387757 | ENSP00000274811 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | Ring finger protein 44 | 0.542 |
HIC2 | TRIM71 | ENSP00000387757 | ENSP00000373272 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and preven [...] | 0.542 |
KCNU1 | HIC2 | ENSP00000382770 | ENSP00000387757 | Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina; Belongs to the potassium channel family. Calcium- a [...] | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.459 |
MBD6 | HIC2 | ENSP00000347896 | ENSP00000387757 | Methyl-CpG-binding domain protein 6; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro); Methyl-CpG binding domain containing | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.615 |
PHF2 | HIC2 | ENSP00000352185 | ENSP00000387757 | Lysine-specific demethylase PHF2; Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA- forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated ’Lys-9’ of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethyl [...] | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing | 0.445 |