• Version:
  • 11.0 [archived version]
STRINGSTRING
OR10S1 OR10S1 DCTN4 DCTN4 PPM1J PPM1J SH3RF1 SH3RF1 PLEKHA6 PLEKHA6 IRGQ IRGQ ATP5SL ATP5SL TULP2 TULP2 HIPK4 HIPK4 TTC9B TTC9B ABRACL ABRACL
"IRGQ" - Immunity-related GTPase family Q protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
IRGQImmunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family (623 aa)    
Predicted Functional Partners:
TTC9B
Tetratricopeptide repeat domain containing (239 aa)
     
   
  0.584
ATP5SL
Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I; Belongs to the ATP synthase subunit s family (263 aa)
           
  0.582
PLEKHA6
Pleckstrin homology domain containing A6 (1048 aa)
     
   
  0.581
PPM1J
Protein phosphatase, Mg2+/Mn2+ dependent 1J (505 aa)
           
  0.564
DCTN4
Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (467 aa)
           
  0.560
OR10S1
Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 (331 aa)
           
  0.554
HIPK4
Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) (616 aa)
           
  0.550
TULP2
Tubby like protein 2; Belongs to the TUB family (520 aa)
           
  0.543
ABRACL
Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family (81 aa)
           
  0.524
SH3RF1
E3 ubiquitin-protein ligase SH3RF1; Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9) (By similarity). May be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane; Belongs to the SH3RF family (888 aa)
     
   
  0.516
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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