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  • 11.0 [archived version]
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MIEN1 MIEN1 CPNE4 CPNE4 NECAB2 NECAB2 ST8SIA3 ST8SIA3 NECAB1 NECAB1 NECAB3 NECAB3 FBLL1 FBLL1 CCDC62 CCDC62 PPP4R4 PPP4R4 ANKRD7 ANKRD7 CCDC24 CCDC24
"NECAB1" - N-terminal EF-hand calcium binding protein 1 in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
NECAB1N-terminal EF-hand calcium binding protein 1; EF-hand domain containing (351 aa)    
Predicted Functional Partners:
NECAB3
N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3; EF-hand domain containing (396 aa)
       
 
0.816
NECAB2
N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation; EF-hand domain containing (386 aa)
     
 
0.738
FBLL1
rRNA/tRNA 2’-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2’-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity); Seven-beta-strand methyltransferase motif containing (334 aa)
     
   
  0.569
CPNE4
Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family (575 aa)
     
 
  0.560
ANKRD7
Ankyrin repeat domain-containing protein 7; Ankyrin repeat domain containing (254 aa)
     
   
  0.528
CCDC62
Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR (684 aa)
           
  0.524
PPP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4; Putative regulatory subunit of serine/threonine-protein phosphatase 4; Armadillo-like helical domain containing (873 aa)
     
   
  0.516
MIEN1
Migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process; Belongs to the SelWTH family (115 aa)
           
  0.513
ST8SIA3
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R-alpha 2,8-sialyltransferase; Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid; Belongs to the glycosyltransferase 29 family (380 aa)
     
   
  0.507
CCDC24
Coiled-coil domain containing 24 (307 aa)
           
  0.497
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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