SERF2 protein (human) - STRING database

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SERF2

Small EDRK-rich factor 2 (170 aa)

Predicted Functional Partners:

HYPK

0.713

MATR3

0.650

MFAP1

0.625

SERINC4

0.543

RPLP1

0.528

FUBP1

0.503

SCAF8

0.489

TMEM14B

0.455

SRP14

0.450

LRRC57

0.440

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FUBP1	MATR3	ENSP00000359804	ENSP00000354346	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins	0.493
FUBP1	MFAP1	ENSP00000359804	ENSP00000267812	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex	0.459
FUBP1	SCAF8	ENSP00000359804	ENSP00000413098	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing	0.437
FUBP1	SERF2	ENSP00000359804	ENSP00000387187	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	Small EDRK-rich factor 2	0.503
HYPK	MFAP1	ENSP00000384474	ENSP00000267812	Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex	0.541
HYPK	SERF2	ENSP00000384474	ENSP00000387187	Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	Small EDRK-rich factor 2	0.713
HYPK	SERINC4	ENSP00000384474	ENSP00000319796	Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	Serine incorporator 4; Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids	0.511
LRRC57	SERF2	ENSP00000326817	ENSP00000387187	Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57	Small EDRK-rich factor 2	0.440
MATR3	FUBP1	ENSP00000354346	ENSP00000359804	Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	0.493
MATR3	SERF2	ENSP00000354346	ENSP00000387187	Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins	Small EDRK-rich factor 2	0.650
MFAP1	FUBP1	ENSP00000267812	ENSP00000359804	Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	0.459
MFAP1	HYPK	ENSP00000267812	ENSP00000384474	Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex	Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	0.541
MFAP1	SERF2	ENSP00000267812	ENSP00000387187	Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex	Small EDRK-rich factor 2	0.625
MFAP1	SERINC4	ENSP00000267812	ENSP00000319796	Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex	Serine incorporator 4; Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids	0.722
RPLP1	SERF2	ENSP00000346037	ENSP00000387187	60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family	Small EDRK-rich factor 2	0.528
RPLP1	SRP14	ENSP00000346037	ENSP00000267884	60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family	Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding	0.939
SCAF8	FUBP1	ENSP00000413098	ENSP00000359804	Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	0.437
SCAF8	SERF2	ENSP00000413098	ENSP00000387187	Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing	Small EDRK-rich factor 2	0.489
SERF2	FUBP1	ENSP00000387187	ENSP00000359804	Small EDRK-rich factor 2	Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription	0.503
SERF2	HYPK	ENSP00000387187	ENSP00000384474	Small EDRK-rich factor 2	Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation	0.713

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