node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FUBP1 | MATR3 | ENSP00000359804 | ENSP00000354346 | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins | 0.493 |
FUBP1 | MFAP1 | ENSP00000359804 | ENSP00000267812 | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | 0.459 |
FUBP1 | SCAF8 | ENSP00000359804 | ENSP00000413098 | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing | 0.437 |
FUBP1 | SERF2 | ENSP00000359804 | ENSP00000387187 | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | Small EDRK-rich factor 2 | 0.503 |
HYPK | MFAP1 | ENSP00000384474 | ENSP00000267812 | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | 0.541 |
HYPK | SERF2 | ENSP00000384474 | ENSP00000387187 | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | Small EDRK-rich factor 2 | 0.713 |
HYPK | SERINC4 | ENSP00000384474 | ENSP00000319796 | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | Serine incorporator 4; Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids | 0.511 |
LRRC57 | SERF2 | ENSP00000326817 | ENSP00000387187 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 | Small EDRK-rich factor 2 | 0.440 |
MATR3 | FUBP1 | ENSP00000354346 | ENSP00000359804 | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | 0.493 |
MATR3 | SERF2 | ENSP00000354346 | ENSP00000387187 | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. May bind to specific miRNA hairpins | Small EDRK-rich factor 2 | 0.650 |
MFAP1 | FUBP1 | ENSP00000267812 | ENSP00000359804 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | 0.459 |
MFAP1 | HYPK | ENSP00000267812 | ENSP00000384474 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | 0.541 |
MFAP1 | SERF2 | ENSP00000267812 | ENSP00000387187 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Small EDRK-rich factor 2 | 0.625 |
MFAP1 | SERINC4 | ENSP00000267812 | ENSP00000319796 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex | Serine incorporator 4; Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids | 0.722 |
RPLP1 | SERF2 | ENSP00000346037 | ENSP00000387187 | 60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family | Small EDRK-rich factor 2 | 0.528 |
RPLP1 | SRP14 | ENSP00000346037 | ENSP00000267884 | 60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family | Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding | 0.939 |
SCAF8 | FUBP1 | ENSP00000413098 | ENSP00000359804 | Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | 0.437 |
SCAF8 | SERF2 | ENSP00000413098 | ENSP00000387187 | Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing | Small EDRK-rich factor 2 | 0.489 |
SERF2 | FUBP1 | ENSP00000387187 | ENSP00000359804 | Small EDRK-rich factor 2 | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription | 0.503 |
SERF2 | HYPK | ENSP00000387187 | ENSP00000384474 | Small EDRK-rich factor 2 | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation | 0.713 |