| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANXA7 | LRRFIP2 | ENSP00000362010 | ENSP00000338727 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family | Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding; Belongs to the LRRFIP family | 0.569 |
| ANXA7 | R3HDM1 | ENSP00000362010 | ENSP00000387010 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family | R3H domain containing 1 | 0.460 |
| COPZ2 | R3HDM1 | ENSP00000480707 | ENSP00000387010 | Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properti [...] | R3H domain containing 1 | 0.616 |
| LEMD3 | R3HDM1 | ENSP00000308369 | ENSP00000387010 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest; LEM domain containing | R3H domain containing 1 | 0.470 |
| LMBRD1 | R3HDM1 | ENSP00000359609 | ENSP00000387010 | Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | R3H domain containing 1 | 0.500 |
| LMBRD1 | RAB3GAP1 | ENSP00000359609 | ENSP00000411418 | Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.462 |
| LRRFIP2 | ANXA7 | ENSP00000338727 | ENSP00000362010 | Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding; Belongs to the LRRFIP family | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family | 0.569 |
| LRRFIP2 | R3HDM1 | ENSP00000338727 | ENSP00000387010 | Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding; Belongs to the LRRFIP family | R3H domain containing 1 | 0.510 |
| MAP3K19 | R3HDM1 | ENSP00000365005 | ENSP00000387010 | Mitogen-activated protein kinase kinase kinase 19; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | R3H domain containing 1 | 0.512 |
| MAP3K19 | RAB3GAP1 | ENSP00000365005 | ENSP00000411418 | Mitogen-activated protein kinase kinase kinase 19; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.451 |
| MAP3K19 | ZRANB3 | ENSP00000365005 | ENSP00000264159 | Mitogen-activated protein kinase kinase kinase 19; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3’-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. [...] | 0.537 |
| R3HDM1 | ANXA7 | ENSP00000387010 | ENSP00000362010 | R3H domain containing 1 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family | 0.460 |
| R3HDM1 | COPZ2 | ENSP00000387010 | ENSP00000480707 | R3H domain containing 1 | Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properti [...] | 0.616 |
| R3HDM1 | LEMD3 | ENSP00000387010 | ENSP00000308369 | R3H domain containing 1 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest; LEM domain containing | 0.470 |
| R3HDM1 | LMBRD1 | ENSP00000387010 | ENSP00000359609 | R3H domain containing 1 | Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in the assembly of hepatitis delta virus (HDV) | 0.500 |
| R3HDM1 | LRRFIP2 | ENSP00000387010 | ENSP00000338727 | R3H domain containing 1 | Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding; Belongs to the LRRFIP family | 0.510 |
| R3HDM1 | MAP3K19 | ENSP00000387010 | ENSP00000365005 | R3H domain containing 1 | Mitogen-activated protein kinase kinase kinase 19; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily | 0.512 |
| R3HDM1 | RAB3GAP1 | ENSP00000387010 | ENSP00000411418 | R3H domain containing 1 | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters | 0.546 |
| R3HDM1 | SMPDL3B | ENSP00000387010 | ENSP00000363001 | R3H domain containing 1 | Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity) | 0.467 |
| R3HDM1 | TMEM163 | ENSP00000387010 | ENSP00000281924 | R3H domain containing 1 | Transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles | 0.507 |
