| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC136 | MEGF11 | ENSP00000297788 | ENSP00000386908 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.585 |
| DTX1 | MEGF11 | ENSP00000257600 | ENSP00000386908 | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.646 |
| DTX1 | RITA1 | ENSP00000257600 | ENSP00000448680 | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | 0.657 |
| ELMO3 | GULP1 | ENSP00000377566 | ENSP00000386289 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 | 0.903 |
| ELMO3 | MEGF11 | ENSP00000377566 | ENSP00000386908 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.550 |
| FRMD4A | GLT1D1 | ENSP00000350032 | ENSP00000281703 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | Glycosyltransferase 1 domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | 0.460 |
| FRMD4A | MEGF11 | ENSP00000350032 | ENSP00000386908 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.563 |
| FRMD4A | RITA1 | ENSP00000350032 | ENSP00000448680 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis | 0.601 |
| GLT1D1 | FRMD4A | ENSP00000281703 | ENSP00000350032 | Glycosyltransferase 1 domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | 0.460 |
| GLT1D1 | MEGF11 | ENSP00000281703 | ENSP00000386908 | Glycosyltransferase 1 domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.692 |
| GLT1D1 | TMEM132C | ENSP00000281703 | ENSP00000410852 | Glycosyltransferase 1 domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits | 0.738 |
| GULP1 | ELMO3 | ENSP00000386289 | ENSP00000377566 | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | 0.903 |
| GULP1 | MEGF11 | ENSP00000386289 | ENSP00000386908 | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.662 |
| LMAN1L | MEGF11 | ENSP00000310431 | ENSP00000386908 | Protein ERGIC-53-like; Lectin, mannose binding 1 like | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | 0.677 |
| MEGF11 | CCDC136 | ENSP00000386908 | ENSP00000297788 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization | 0.585 |
| MEGF11 | DTX1 | ENSP00000386908 | ENSP00000257600 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibi [...] | 0.646 |
| MEGF11 | ELMO3 | ENSP00000386908 | ENSP00000377566 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity) | 0.550 |
| MEGF11 | FRMD4A | ENSP00000386908 | ENSP00000350032 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling; FERM domain containing | 0.563 |
| MEGF11 | GLT1D1 | ENSP00000386908 | ENSP00000281703 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | Glycosyltransferase 1 domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily | 0.692 |
| MEGF11 | GULP1 | ENSP00000386908 | ENSP00000386289 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity); Belongs to the MEGF family | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6 | 0.662 |
