node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATXN10 | DCDC2B | ENSP00000252934 | ENSP00000386870 | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis; Armadillo-like helical domain containing | Doublecortin domain containing 2B | 0.686 |
DCDC1 | DCDC2B | ENSP00000385936 | ENSP00000386870 | Doublecortin domain-containing protein 5; Doublecortin domain containing 1 | Doublecortin domain containing 2B | 0.806 |
DCDC2B | ATXN10 | ENSP00000386870 | ENSP00000252934 | Doublecortin domain containing 2B | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis; Armadillo-like helical domain containing | 0.686 |
DCDC2B | DCDC1 | ENSP00000386870 | ENSP00000385936 | Doublecortin domain containing 2B | Doublecortin domain-containing protein 5; Doublecortin domain containing 1 | 0.806 |
DCDC2B | DCLK3 | ENSP00000386870 | ENSP00000394484 | Doublecortin domain containing 2B | Serine/threonine-protein kinase DCLK3; Doublecortin like kinase 3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily | 0.811 |
DCDC2B | DYX1C1 | ENSP00000386870 | ENSP00000323275 | Doublecortin domain containing 2B | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.503 |
DCDC2B | GAK | ENSP00000386870 | ENSP00000314499 | Doublecortin domain containing 2B | Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.483 |
DCDC2B | KIAA0319 | ENSP00000386870 | ENSP00000367459 | Doublecortin domain containing 2B | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | 0.492 |
DCDC2B | MAPK8IP2 | ENSP00000386870 | ENSP00000330572 | Doublecortin domain containing 2B | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.455 |
DCDC2B | PPP1R9B | ENSP00000386870 | ENSP00000478767 | Doublecortin domain containing 2B | Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Pla [...] | 0.550 |
DCLK3 | DCDC2B | ENSP00000394484 | ENSP00000386870 | Serine/threonine-protein kinase DCLK3; Doublecortin like kinase 3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily | Doublecortin domain containing 2B | 0.811 |
DCLK3 | MAPK8IP2 | ENSP00000394484 | ENSP00000330572 | Serine/threonine-protein kinase DCLK3; Doublecortin like kinase 3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.638 |
DCLK3 | PPP1R9B | ENSP00000394484 | ENSP00000478767 | Serine/threonine-protein kinase DCLK3; Doublecortin like kinase 3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily | Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Pla [...] | 0.664 |
DYX1C1 | DCDC2B | ENSP00000323275 | ENSP00000386870 | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | Doublecortin domain containing 2B | 0.503 |
DYX1C1 | KIAA0319 | ENSP00000323275 | ENSP00000367459 | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | 0.923 |
GAK | DCDC2B | ENSP00000314499 | ENSP00000386870 | Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Doublecortin domain containing 2B | 0.483 |
GAK | KIAA0319 | ENSP00000314499 | ENSP00000367459 | Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | 0.901 |
KIAA0319 | DCDC2B | ENSP00000367459 | ENSP00000386870 | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | Doublecortin domain containing 2B | 0.492 |
KIAA0319 | DYX1C1 | ENSP00000367459 | ENSP00000323275 | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.923 |
KIAA0319 | GAK | ENSP00000367459 | ENSP00000314499 | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites | Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.901 |