XIRP2 protein (human) - STRING database

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XIRP2

Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family (3549 aa)

Predicted Functional Partners:

ACTN2

0.686

FLNC

0.658

MEF2A

0.641

NRAP

0.628

NEBL

0.581

FSCN2

0.548

NEB

0.539

CNBD1

0.536

MYOT

0.524

TTC29

0.491

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	MYOT	ENSP00000443495	ENSP00000239926	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	0.648
ACTN2	NEB	ENSP00000443495	ENSP00000484342	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	Nebulin	0.954
ACTN2	NEBL	ENSP00000443495	ENSP00000366326	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion; LIM domain containing	0.554
ACTN2	NRAP	ENSP00000443495	ENSP00000358365	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	Nebulin-related-anchoring protein; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix; LIM domain containing	0.635
ACTN2	XIRP2	ENSP00000443495	ENSP00000386840	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family	0.686
CNBD1	XIRP2	ENSP00000430073	ENSP00000386840	Cyclic nucleotide-binding domain-containing protein 1; Cyclic nucleotide binding domain containing 1	Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family	0.536
FLNC	MYOT	ENSP00000327145	ENSP00000239926	Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	0.876
FLNC	NEB	ENSP00000327145	ENSP00000484342	Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	Nebulin	0.624
FLNC	NEBL	ENSP00000327145	ENSP00000366326	Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion; LIM domain containing	0.671
FLNC	NRAP	ENSP00000327145	ENSP00000358365	Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	Nebulin-related-anchoring protein; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix; LIM domain containing	0.523
FLNC	XIRP2	ENSP00000327145	ENSP00000386840	Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family	0.658
FSCN2	XIRP2	ENSP00000334665	ENSP00000386840	Fascin-2; Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis; Fascins	Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family	0.548
MEF2A	XIRP2	ENSP00000346389	ENSP00000386840	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylat [...]	Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family	0.641
MYOT	ACTN2	ENSP00000239926	ENSP00000443495	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	0.648
MYOT	FLNC	ENSP00000239926	ENSP00000327145	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers	0.876
MYOT	NEB	ENSP00000239926	ENSP00000484342	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	Nebulin	0.741
MYOT	NEBL	ENSP00000239926	ENSP00000366326	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Isoform 2 might play a role in the assembly of focal adhesion; LIM domain containing	0.601
MYOT	NRAP	ENSP00000239926	ENSP00000358365	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	Nebulin-related-anchoring protein; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix; LIM domain containing	0.446
MYOT	XIRP2	ENSP00000239926	ENSP00000386840	Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing	Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family	0.524
NEB	ACTN2	ENSP00000484342	ENSP00000443495	Nebulin	Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins	0.954

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